MR1L1_HUMAN
ID MR1L1_HUMAN Reviewed; 127 AA.
AC Q96HT8; B2R6R0; Q6NXT8; Q9P0J5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=MORF4 family-associated protein 1-like 1;
GN Name=MRFAP1L1; ORFNames=PP784;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Adrenal gland;
RX PubMed=10931946; DOI=10.1073/pnas.160270997;
RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA Chen M.-D., Chen J.-L.;
RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT and full-length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hippocampus, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96HT8; Q9NYB9: ABI2; NbExp=7; IntAct=EBI-748896, EBI-743598;
CC Q96HT8; Q9P2A4: ABI3; NbExp=3; IntAct=EBI-748896, EBI-742038;
CC Q96HT8; P54253: ATXN1; NbExp=6; IntAct=EBI-748896, EBI-930964;
CC Q96HT8; Q13895: BYSL; NbExp=13; IntAct=EBI-748896, EBI-358049;
CC Q96HT8; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-748896, EBI-747505;
CC Q96HT8; Q6ZUJ4: C3orf62; NbExp=4; IntAct=EBI-748896, EBI-2837036;
CC Q96HT8; Q8TC20: CAGE1; NbExp=3; IntAct=EBI-748896, EBI-10196469;
CC Q96HT8; Q969G5: CAVIN3; NbExp=6; IntAct=EBI-748896, EBI-3893101;
CC Q96HT8; O14519: CDK2AP1; NbExp=7; IntAct=EBI-748896, EBI-1052532;
CC Q96HT8; O75956: CDK2AP2; NbExp=3; IntAct=EBI-748896, EBI-2808135;
CC Q96HT8; Q9BS16: CENPK; NbExp=3; IntAct=EBI-748896, EBI-6871750;
CC Q96HT8; Q9C0F1: CEP44; NbExp=3; IntAct=EBI-748896, EBI-744115;
CC Q96HT8; Q1MSJ5-2: CSPP1; NbExp=3; IntAct=EBI-748896, EBI-10239155;
CC Q96HT8; Q6IAV4: DOC-1R; NbExp=3; IntAct=EBI-748896, EBI-724649;
CC Q96HT8; Q53XC2: EIF2B2; NbExp=3; IntAct=EBI-748896, EBI-10288660;
CC Q96HT8; Q9BPX4: EIF2B2; NbExp=3; IntAct=EBI-748896, EBI-10288788;
CC Q96HT8; O95995: GAS8; NbExp=3; IntAct=EBI-748896, EBI-1052570;
CC Q96HT8; Q9UHL9: GTF2IRD1; NbExp=3; IntAct=EBI-748896, EBI-372530;
CC Q96HT8; O14964: HGS; NbExp=6; IntAct=EBI-748896, EBI-740220;
CC Q96HT8; P01112: HRAS; NbExp=3; IntAct=EBI-748896, EBI-350145;
CC Q96HT8; P42858: HTT; NbExp=21; IntAct=EBI-748896, EBI-466029;
CC Q96HT8; Q8IYA8: IHO1; NbExp=7; IntAct=EBI-748896, EBI-8638439;
CC Q96HT8; O60333-2: KIF1B; NbExp=3; IntAct=EBI-748896, EBI-10975473;
CC Q96HT8; O14901: KLF11; NbExp=3; IntAct=EBI-748896, EBI-948266;
CC Q96HT8; P25791: LMO2; NbExp=3; IntAct=EBI-748896, EBI-739696;
CC Q96HT8; Q8TBB1: LNX1; NbExp=7; IntAct=EBI-748896, EBI-739832;
CC Q96HT8; Q8N448: LNX2; NbExp=4; IntAct=EBI-748896, EBI-2340947;
CC Q96HT8; P27361: MAPK3; NbExp=3; IntAct=EBI-748896, EBI-73995;
CC Q96HT8; P50222: MEOX2; NbExp=3; IntAct=EBI-748896, EBI-748397;
CC Q96HT8; Q9UBU8: MORF4L1; NbExp=9; IntAct=EBI-748896, EBI-399246;
CC Q96HT8; Q9UBU8-2: MORF4L1; NbExp=27; IntAct=EBI-748896, EBI-10288852;
CC Q96HT8; Q15014: MORF4L2; NbExp=11; IntAct=EBI-748896, EBI-399257;
CC Q96HT8; Q9Y605: MRFAP1; NbExp=6; IntAct=EBI-748896, EBI-995714;
CC Q96HT8; Q96HT8: MRFAP1L1; NbExp=11; IntAct=EBI-748896, EBI-748896;
CC Q96HT8; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-748896, EBI-741158;
CC Q96HT8; Q8WWB5: PIH1D2; NbExp=8; IntAct=EBI-748896, EBI-10232538;
CC Q96HT8; O00459: PIK3R2; NbExp=4; IntAct=EBI-748896, EBI-346930;
CC Q96HT8; P60891: PRPS1; NbExp=3; IntAct=EBI-748896, EBI-749195;
CC Q96HT8; P49810: PSEN2; NbExp=3; IntAct=EBI-748896, EBI-2010251;
CC Q96HT8; P25786: PSMA1; NbExp=4; IntAct=EBI-748896, EBI-359352;
CC Q96HT8; Q96JH8: RADIL; NbExp=3; IntAct=EBI-748896, EBI-744267;
CC Q96HT8; Q8NG50: RDM1; NbExp=3; IntAct=EBI-748896, EBI-10288724;
CC Q96HT8; O00560: SDCBP; NbExp=8; IntAct=EBI-748896, EBI-727004;
CC Q96HT8; Q86XK3: SFR1; NbExp=3; IntAct=EBI-748896, EBI-1104535;
CC Q96HT8; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-748896, EBI-455078;
CC Q96HT8; Q2TAY7: SMU1; NbExp=7; IntAct=EBI-748896, EBI-298027;
CC Q96HT8; Q8N0S2: SYCE1; NbExp=3; IntAct=EBI-748896, EBI-6872807;
CC Q96HT8; P15884: TCF4; NbExp=3; IntAct=EBI-748896, EBI-533224;
CC Q96HT8; Q8IUX1: TMEM126B; NbExp=3; IntAct=EBI-748896, EBI-2800657;
CC Q96HT8; Q99757: TXN2; NbExp=6; IntAct=EBI-748896, EBI-2932492;
CC Q96HT8; Q9HAC8: UBTD1; NbExp=8; IntAct=EBI-748896, EBI-745871;
CC Q96HT8; O76024: WFS1; NbExp=3; IntAct=EBI-748896, EBI-720609;
CC Q96HT8; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-748896, EBI-740727;
CC -!- SIMILARITY: Belongs to the MORF4 family-associated protein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF67011.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF155654; AAF67011.1; ALT_FRAME; mRNA.
DR EMBL; AF258591; AAG23794.1; -; mRNA.
DR EMBL; AK312676; BAG35557.1; -; mRNA.
DR EMBL; CH471131; EAW82383.1; -; Genomic_DNA.
DR EMBL; BC008087; AAH08087.1; -; mRNA.
DR EMBL; BC066897; AAH66897.1; -; mRNA.
DR CCDS; CCDS3392.1; -.
DR RefSeq; NP_982287.1; NM_203462.2.
DR RefSeq; XP_005247989.1; XM_005247932.1.
DR AlphaFoldDB; Q96HT8; -.
DR SMR; Q96HT8; -.
DR BioGRID; 125400; 113.
DR DIP; DIP-29019N; -.
DR IntAct; Q96HT8; 57.
DR MINT; Q96HT8; -.
DR STRING; 9606.ENSP00000318154; -.
DR iPTMnet; Q96HT8; -.
DR PhosphoSitePlus; Q96HT8; -.
DR BioMuta; MRFAP1L1; -.
DR DMDM; 74731978; -.
DR EPD; Q96HT8; -.
DR jPOST; Q96HT8; -.
DR MassIVE; Q96HT8; -.
DR MaxQB; Q96HT8; -.
DR PaxDb; Q96HT8; -.
DR PeptideAtlas; Q96HT8; -.
DR PRIDE; Q96HT8; -.
DR ProteomicsDB; 76784; -.
DR Antibodypedia; 67834; 99 antibodies from 14 providers.
DR DNASU; 114932; -.
DR Ensembl; ENST00000320848.7; ENSP00000318154.6; ENSG00000178988.11.
DR GeneID; 114932; -.
DR KEGG; hsa:114932; -.
DR MANE-Select; ENST00000320848.7; ENSP00000318154.6; NM_203462.3; NP_982287.1.
DR UCSC; uc003gjo.5; human.
DR CTD; 114932; -.
DR GeneCards; MRFAP1L1; -.
DR HGNC; HGNC:28796; MRFAP1L1.
DR HPA; ENSG00000178988; Low tissue specificity.
DR neXtProt; NX_Q96HT8; -.
DR OpenTargets; ENSG00000178988; -.
DR PharmGKB; PA142671333; -.
DR VEuPathDB; HostDB:ENSG00000178988; -.
DR eggNOG; ENOG502TG9W; Eukaryota.
DR GeneTree; ENSGT00940000155541; -.
DR HOGENOM; CLU_166966_1_0_1; -.
DR InParanoid; Q96HT8; -.
DR OMA; WRIERSS; -.
DR OrthoDB; 1557272at2759; -.
DR PhylomeDB; Q96HT8; -.
DR TreeFam; TF338232; -.
DR PathwayCommons; Q96HT8; -.
DR SignaLink; Q96HT8; -.
DR BioGRID-ORCS; 114932; 9 hits in 1076 CRISPR screens.
DR ChiTaRS; MRFAP1L1; human.
DR GenomeRNAi; 114932; -.
DR Pharos; Q96HT8; Tdark.
DR PRO; PR:Q96HT8; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q96HT8; protein.
DR Bgee; ENSG00000178988; Expressed in cortical plate and 213 other tissues.
DR ExpressionAtlas; Q96HT8; baseline and differential.
DR Genevisible; Q96HT8; HS.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR InterPro; IPR029254; MRFAP1.
DR PANTHER; PTHR31324; PTHR31324; 1.
DR Pfam; PF15155; MRFAP1; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..127
FT /note="MORF4 family-associated protein 1-like 1"
FT /id="PRO_0000318718"
FT COILED 87..118
FT /evidence="ECO:0000255"
FT CONFLICT 33
FT /note="N -> H (in Ref. 5; AAH66897)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 127 AA; 14808 MW; 6C914B0B4BEECAE5 CRC64;
MRPLDIDEVE APEEVEVLEP EEDFEQFLLP VINEMREDIA SLIREHGRAY LRTRSKLWEM
DNMLIQIKTQ VEASEESALN HVQHPSGEAD ERVSELCEKA EEKAKEIAKM AEMLVELVWR
IERSESS
