ID   MRAP_PANTR              Reviewed;         172 AA.
AC   Q68UT4; Q68UT3;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Melanocortin-2 receptor accessory protein;
DE   AltName: Full=Fat cell-specific low molecular weight protein;
DE   AltName: Full=Fat tissue-specific low MW protein;
GN   Name=MRAP; Synonyms=FALP;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164055; DOI=10.1038/nature02564;
RA   Watanabe H., Fujiyama A., Hattori M., Taylor T.D., Toyoda A., Kuroki Y.,
RA   Noguchi H., BenKahla A., Lehrach H., Sudbrak R., Kube M., Taenzer S.,
RA   Galgoczy P., Platzer M., Scharfe M., Nordsiek G., Bloecker H., Hellmann I.,
RA   Khaitovich P., Paeaebo S., Reinhardt R., Zheng H.-J., Zhang X.-L.,
RA   Zhu G.-F., Wang B.-F., Fu G., Ren S.-X., Zhao G.-P., Chen Z., Lee Y.-S.,
RA   Cheong J.-E., Choi S.-H., Wu K.-M., Liu T.-T., Hsiao K.-J., Tsai S.-F.,
RA   Kim C.-G., Oota S., Kitano T., Kohara Y., Saitou N., Park H.-S.,
RA   Wang S.-Y., Yaspo M.-L., Sakaki Y.;
RT   "DNA sequence and comparative analysis of chimpanzee chromosome 22.";
RL   Nature 429:382-388(2004).
CC   -!- FUNCTION: Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R
CC       and MC5R). Acts by increasing ligand-sensitivity of melanocortin
CC       receptors and enhancing generation of cAMP by the receptors. Required
CC       both for MC2R trafficking to the cell surface of adrenal cells and for
CC       signaling in response to corticotropin (ACTH). May be involved in the
CC       intracellular trafficking pathways in adipocyte cells (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer and heterodimer. Forms antiparallel homodimers and
CC       heterodimers with MRAP2. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC       protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}. Note=The formation of
CC       antiparallel homo- and heterodimers suggest that N- and C-terminus can
CC       both localize in the cytoplasmic and extracellular parts, depending on
CC       the context. Upon insulin stimulation, it is redistributed into spotty
CC       structures throughout the cytoplasm (By similarity). {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q68UT4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q68UT4-2; Sequence=VSP_011938;
CC   -!- SIMILARITY: Belongs to the MRAP family. {ECO:0000305}.
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DR   EMBL; AL954205; CAH18577.1; -; Genomic_DNA.
DR   EMBL; AL954205; CAH18578.1; -; Genomic_DNA.
DR   RefSeq; NP_001065291.2; NM_001071823.1.
DR   AlphaFoldDB; Q68UT4; -.
DR   STRING; 9598.ENSPTRP00000055057; -.
DR   PaxDb; Q68UT4; -.
DR   GeneID; 746245; -.
DR   KEGG; ptr:746245; -.
DR   CTD; 56246; -.
DR   eggNOG; ENOG502SB3E; Eukaryota.
DR   HOGENOM; CLU_133578_0_0_1; -.
DR   InParanoid; Q68UT4; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0031780; F:corticotropin hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0030545; F:signaling receptor regulator activity; IBA:GO_Central.
DR   GO; GO:0070996; F:type 1 melanocortin receptor binding; IBA:GO_Central.
DR   GO; GO:0031781; F:type 3 melanocortin receptor binding; IBA:GO_Central.
DR   GO; GO:0031782; F:type 4 melanocortin receptor binding; IBA:GO_Central.
DR   GO; GO:0031783; F:type 5 melanocortin receptor binding; IBA:GO_Central.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR   GO; GO:0106070; P:regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR028111; MRAP.
DR   PANTHER; PTHR28675; PTHR28675; 1.
DR   Pfam; PF15183; MRAP; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Cell membrane; Endoplasmic reticulum; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..172
FT                   /note="Melanocortin-2 receptor accessory protein"
FT                   /id="PRO_0000096572"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          105..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          152..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..59
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_011938"
SQ   SEQUENCE   172 AA;  19164 MW;  A1FE41D26701CCBC CRC64;
     MANGTNASAP YYSYEYYLDY LDLIPVDEKK LKAHKHSIVI AFWVSLAAFV VLLFLILLYM
     SWSGSPQMRN SPKHHQTCPW SHGLNLHLCI QKCLPCHREP LATSQAQASS VEPGSRTGPD
     QPLRQESSST LPLGVFQTHP TLLWELTLNG GPLVRSKPSE PPPGDRTSQL QS