ID   ARNR1_SULAC             Reviewed;         269 AA.
AC   Q4J9L2;
DT   12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=HTH-type transcriptional activator ArnR1 {ECO:0000305};
DE   AltName: Full=Archaellum regulatory network protein ArnR1 {ECO:0000305};
GN   Name=arnR1 {ECO:0000303|PubMed:23461567};
GN   OrderedLocusNames=Saci_1171 {ECO:0000312|EMBL:AAY80518.1};
OS   Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC
OS   15157 / NCIMB 11770).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=330779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX   PubMed=15995215; DOI=10.1128/jb.187.14.4992-4999.2005;
RA   Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E.,
RA   Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.;
RT   "The genome of Sulfolobus acidocaldarius, a model organism of the
RT   Crenarchaeota.";
RL   J. Bacteriol. 187:4992-4999(2005).
RN   [2]
RP   FUNCTION AS A REGULATOR, SUBCELLULAR LOCATION, INDUCTION, AND DISRUPTION
RP   PHENOTYPE.
RC   STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX   PubMed=23461567; DOI=10.1111/mmi.12173;
RA   Lassak K., Peeters E., Wrobel S., Albers S.V.;
RT   "The one-component system ArnR: a membrane-bound activator of the
RT   crenarchaeal archaellum.";
RL   Mol. Microbiol. 88:125-139(2013).
CC   -!- FUNCTION: Involved in regulation of archaellar gene expression. May
CC       activate flaB transcription upon nutrient starvation by acting on the
CC       flaB promoter. {ECO:0000269|PubMed:23461567}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23461567};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- INDUCTION: Not induced under starvation conditions.
CC       {ECO:0000269|PubMed:23461567}.
CC   -!- DISRUPTION PHENOTYPE: Deletion results in impaired swimming motility.
CC       {ECO:0000269|PubMed:23461567}.
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DR   EMBL; CP000077; AAY80518.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4J9L2; -.
DR   SMR; Q4J9L2; -.
DR   EnsemblBacteria; AAY80518; AAY80518; Saci_1171.
DR   KEGG; sai:Saci_1171; -.
DR   PATRIC; fig|330779.12.peg.1135; -.
DR   eggNOG; arCOG05969; Archaea.
DR   HOGENOM; CLU_1032970_0_0_2; -.
DR   OMA; ISITQPW; -.
DR   Proteomes; UP000001018; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR038723; ArnR1-like_HTH.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF14947; HTH_45; 1.
DR   SUPFAM; SSF46785; SSF46785; 2.
PE   1: Evidence at protein level;
KW   Activator; Cell membrane; DNA-binding; Membrane; Reference proteome;
KW   Transcription; Transcription regulation; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..269
FT                   /note="HTH-type transcriptional activator ArnR1"
FT                   /id="PRO_0000439512"
FT   TOPO_DOM        1..217
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305|PubMed:23461567"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        239..241
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305|PubMed:23461567"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        263..269
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305|PubMed:23461567"
FT   DNA_BIND        42..65
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   269 AA;  30786 MW;  F2F4FFB04D523FAD CRC64;
     MSSMNKRVFD ILRELDSLVD FSRAKLQWDI LIILATKGPS STTEISQTIN TSRKSIIDAI
     RKLVDKELVT KVKGDIYGLS EKGEKLLESF DSIMSINVTD KPDSSIESNS ISLTNIAEYF
     YMLEILKMAL LNKQITIDKA SHELGISKQT LKYYIETFTE NKLLKVVNQE SVLGKSKKIY
     VLTDESRKLV SRLPELTRLK RNLPLKILLK LTGSYRYEIA LTKVMLFNVI SIPVLMYLKD
     QLGILEAIWL YVIILLPLLS IFAEIFNRI