ARNR_SULAC
ID ARNR_SULAC Reviewed; 269 AA.
AC Q4J9J9;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=HTH-type transcriptional activator ArnR {ECO:0000305};
DE AltName: Full=Archaellum regulatory network protein ArnR {ECO:0000305};
GN Name=arnR {ECO:0000303|PubMed:23461567};
GN OrderedLocusNames=Saci_1180 {ECO:0000312|EMBL:AAY80527.1};
OS Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC
OS 15157 / NCIMB 11770).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=330779;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX PubMed=15995215; DOI=10.1128/jb.187.14.4992-4999.2005;
RA Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E.,
RA Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.;
RT "The genome of Sulfolobus acidocaldarius, a model organism of the
RT Crenarchaeota.";
RL J. Bacteriol. 187:4992-4999(2005).
RN [2]
RP FUNCTION AS A REGULATOR, SUBCELLULAR LOCATION, INDUCTION, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX PubMed=23461567; DOI=10.1111/mmi.12173;
RA Lassak K., Peeters E., Wrobel S., Albers S.V.;
RT "The one-component system ArnR: a membrane-bound activator of the
RT crenarchaeal archaellum.";
RL Mol. Microbiol. 88:125-139(2013).
RN [3]
RP REGULATION BY ARNS.
RC STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX PubMed=27731916; DOI=10.1111/mmi.13550;
RA Haurat M.F., Figueiredo A.S., Hoffmann L., Li L., Herr K., Wilson A.J.,
RA Beeby M., Schaber J., Albers S.-V.;
RT "ArnS, a kinase involved in starvation-induced archaellum expression.";
RL Mol. Microbiol. 103:181-194(2017).
CC -!- FUNCTION: Involved in regulation of archaellar gene expression.
CC Activates flaB transcription upon nutrient starvation by acting on the
CC flaB promoter. {ECO:0000269|PubMed:23461567}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23461567};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- INDUCTION: Induced during starvation conditions (PubMed:23461567).
CC Regulated by ArnS (PubMed:27731916). {ECO:0000269|PubMed:23461567,
CC ECO:0000269|PubMed:27731916}.
CC -!- DISRUPTION PHENOTYPE: Deletion results in diminished flaB expression
CC and strongly impaired swimming motility. {ECO:0000269|PubMed:23461567}.
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DR EMBL; CP000077; AAY80527.1; -; Genomic_DNA.
DR RefSeq; WP_011278029.1; NC_007181.1.
DR AlphaFoldDB; Q4J9J9; -.
DR STRING; 330779.Saci_1180; -.
DR EnsemblBacteria; AAY80527; AAY80527; Saci_1180.
DR GeneID; 3473525; -.
DR KEGG; sai:Saci_1180; -.
DR PATRIC; fig|330779.12.peg.1144; -.
DR eggNOG; arCOG05969; Archaea.
DR HOGENOM; CLU_1032970_0_0_2; -.
DR OMA; IFAYLTM; -.
DR Proteomes; UP000001018; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000835; HTH_MarR-typ.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01047; MarR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 1: Evidence at protein level;
KW Activator; Cell membrane; DNA-binding; Membrane; Reference proteome;
KW Stress response; Transcription; Transcription regulation; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..269
FT /note="HTH-type transcriptional activator ArnR"
FT /id="PRO_0000439511"
FT TOPO_DOM 1..218
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:23461567"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..242
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:23461567"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..269
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:23461567"
FT DNA_BIND 39..62
FT /note="H-T-H motif"
FT /evidence="ECO:0000305"
SQ SEQUENCE 269 AA; 31103 MW; C4C271667B911DE8 CRC64;
MTKSLFDVLK ELDSLVDFSR AKLQWDILII LATKGPSSTT EISQTINTSR KSIIDAIRKL
VDKELVTKVK HDIYGLSDKG KELWNKIDSV LNIEVINGNN HKGQSKDEDI LALENLSQYF
YLINLSKMIT INHDGLSLDK AARELGVSRQ TLKYYLELFE EKKLFRVIGK RTHFKKNIYK
CVLMNEGKRL LFRLPEFTKM KNNLPLKLLL RLTNSYTLEM ANVKVMGFIL ISLPLLMYFR
DQLGLIELPW LYAVIFLALL SVFAQILSR
