ARNT2_RAT
ID ARNT2_RAT Reviewed; 712 AA.
AC Q78E60; Q30B64; Q63643; Q63646; Q80T24;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Aryl hydrocarbon receptor nuclear translocator 2;
DE Short=ARNT protein 2;
GN Name=Arnt2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=Sprague-Dawley;
RA Drutel G.;
RT "Nucleotide sequence of rat Arnt2.";
RL Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=Long Evans;
RX PubMed=12684048; DOI=10.1016/s0006-291x(03)00489-3;
RA Korkalainen M., Tuomisto J., Pohjanvirta R.;
RT "Identification of novel splice variants of ARNT and ARNT2 in the rat.";
RL Biochem. Biophys. Res. Commun. 303:1095-1100(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RA Linguang S., Wei Y., Yijun H., Wenfang C., Xingwen S., Pengxin Q.,
RA Guangmei Y.;
RT "Low potassium induces Arnt2 overexpression in cerebellar granule
RT neurons.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that plays a role in the development of
CC the hypothalamo-pituitary axis, postnatal brain growth, and visual and
CC renal function. Specifically recognizes the xenobiotic response element
CC (XRE). {ECO:0000250|UniProtKB:Q9HBZ2}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein (By similarity). Heterodimer with NPAS4 or SIM1 (By
CC similarity). Heterodimer with the aryl hydrocarbon receptor (AHR) or
CC the SIM1 protein (By similarity). Interacts with TACC3 (By similarity).
CC {ECO:0000250|UniProtKB:Q61324, ECO:0000250|UniProtKB:Q9HBZ2}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9HBZ2,
CC ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q78E60-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q78E60-2; Sequence=VSP_022690;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB05247.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U61157; AAB05247.1; ALT_INIT; mRNA.
DR EMBL; U61405; AAB03666.1; -; mRNA.
DR EMBL; AY264366; AAO89095.1; -; mRNA.
DR EMBL; DQ223732; ABB17190.1; -; mRNA.
DR RefSeq; NP_036913.3; NM_012781.3. [Q78E60-1]
DR RefSeq; XP_006229560.1; XM_006229498.2. [Q78E60-2]
DR AlphaFoldDB; Q78E60; -.
DR SMR; Q78E60; -.
DR STRING; 10116.ENSRNOP00000017636; -.
DR CarbonylDB; Q78E60; -.
DR iPTMnet; Q78E60; -.
DR PhosphoSitePlus; Q78E60; -.
DR PaxDb; Q78E60; -.
DR Ensembl; ENSRNOT00000105581; ENSRNOP00000084711; ENSRNOG00000063992. [Q78E60-1]
DR Ensembl; ENSRNOT00000107318; ENSRNOP00000087722; ENSRNOG00000013017. [Q78E60-1]
DR GeneID; 25243; -.
DR KEGG; rno:25243; -.
DR UCSC; RGD:2154; rat. [Q78E60-1]
DR CTD; 9915; -.
DR RGD; 2154; Arnt2.
DR eggNOG; KOG3561; Eukaryota.
DR GeneTree; ENSGT00940000158198; -.
DR HOGENOM; CLU_011864_1_1_1; -.
DR InParanoid; Q78E60; -.
DR OMA; MRPFSAN; -.
DR OrthoDB; 331262at2759; -.
DR PhylomeDB; Q78E60; -.
DR TreeFam; TF319983; -.
DR Reactome; R-RNO-211945; Phase I - Functionalization of compounds.
DR Reactome; R-RNO-211976; Endogenous sterols.
DR Reactome; R-RNO-211981; Xenobiotics.
DR Reactome; R-RNO-8937144; Aryl hydrocarbon receptor signalling.
DR PRO; PR:Q78E60; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000013017; Expressed in frontal cortex and 15 other tissues.
DR Genevisible; Q78E60; RN.
DR GO; GO:0034751; C:aryl hydrocarbon receptor complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0005667; C:transcription regulator complex; ISO:RGD.
DR GO; GO:0017162; F:aryl hydrocarbon receptor binding; ISO:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0046982; F:protein heterodimerization activity; ISO:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; IDA:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR GO; GO:0007417; P:central nervous system development; ISO:RGD.
DR GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0032355; P:response to estradiol; IEP:RGD.
DR GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; SSF47459; 1.
DR SUPFAM; SSF55785; SSF55785; 2.
DR TIGRFAMs; TIGR00229; sensory_box; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Methylation; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation.
FT CHAIN 1..712
FT /note="Aryl hydrocarbon receptor nuclear translocator 2"
FT /id="PRO_0000275900"
FT DOMAIN 63..116
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT DOMAIN 134..209
FT /note="PAS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT DOMAIN 323..393
FT /note="PAS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT DOMAIN 398..441
FT /note="PAC"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 35..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 42
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q61324"
FT VAR_SEQ 681..712
FT /note="DMLPMPGDPTQGTGNYNIEDFADLGMFPPFSE -> VNPASSAFS (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:12684048"
FT /id="VSP_022690"
FT CONFLICT 456
FT /note="L -> P (in Ref. 2; ABB17190)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 712 AA; 77958 MW; 649A8AA41E120320 CRC64;
MATPAAVNPP EMASDIPGSV TLPVAPMAAT GQVRMAGAMP ARGGKRRSGM DFDDEDGEGP
SKFSRENHSE IERRRRNKMT QYITELSDMV PTCSALARKP DKLTILRMAV SHMKSMRGTG
NKSTDGAYKP SFLTEQELKH LILEAADGFL FVVAAETGRV IYVSDSVTPV LNQPQSEWFG
STLYEQVHPD DVEKLREQLC TSENSMTGRI LDLKTGTVKK EGQQSSMRMC MGSRRSFICR
MRCGNAPLDH LPLNRITTMR KRFRNGLGPV KEGEAQYAVV HCTGYIKAWP PAGMSIPEED
ADVGQGSKYC LVAIGRLQVT SSPVCMDMSG MSVPTEFLSR HNSDGIITFV DPRCISVIGY
QPQDLLGKDI LEFCHPEDQS HLRESFQQVV KLKGQVLSVM YRFRTKNREW LLIRTSSFTF
QNPYSDEIEY VICTNTNVKQ LQQQQAELEV HQRDGLSSYD LSQVPVPNLP TGVHEAGKPV
EKADAIFSQE RDPRFAEMFA GISASEKKMM SSASASGSQQ IYSQGSPFPA GHSGKAFSSS
VVHVPGVNDI QSSSSTGQNI SQISRQLNQG QVAWTGSRPP FPGQPSKTQS SAFGIGSSHP
YPADPSSYSP LSSPAASSPS GNAYPSLANR TPGFAESGQS GGQFQGRPSE VWSQWQSQHH
GQQSGEQHSH QQPGQTEVFQ DMLPMPGDPT QGTGNYNIED FADLGMFPPF SE
