6PGL_SALTY
ID 6PGL_SALTY Reviewed; 331 AA.
AC Q8ZQR4;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=6-phosphogluconolactonase {ECO:0000255|HAMAP-Rule:MF_01605};
DE Short=6-P-gluconolactonase {ECO:0000255|HAMAP-Rule:MF_01605};
DE EC=3.1.1.31 {ECO:0000255|HAMAP-Rule:MF_01605};
GN Name=pgl {ECO:0000255|HAMAP-Rule:MF_01605}; OrderedLocusNames=STM0785;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-
CC phosphogluconate. {ECO:0000255|HAMAP-Rule:MF_01605}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01605};
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC 2/3. {ECO:0000255|HAMAP-Rule:MF_01605}.
CC -!- SIMILARITY: Belongs to the cycloisomerase 2 family. {ECO:0000255|HAMAP-
CC Rule:MF_01605}.
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DR EMBL; AE006468; AAL19723.1; -; Genomic_DNA.
DR RefSeq; NP_459764.1; NC_003197.2.
DR RefSeq; WP_000815468.1; NC_003197.2.
DR AlphaFoldDB; Q8ZQR4; -.
DR SMR; Q8ZQR4; -.
DR STRING; 99287.STM0785; -.
DR PaxDb; Q8ZQR4; -.
DR EnsemblBacteria; AAL19723; AAL19723; STM0785.
DR GeneID; 1252305; -.
DR KEGG; stm:STM0785; -.
DR PATRIC; fig|99287.12.peg.818; -.
DR HOGENOM; CLU_038716_2_0_6; -.
DR OMA; EGNWPRD; -.
DR PhylomeDB; Q8ZQR4; -.
DR BioCyc; SENT99287:STM0785-MON; -.
DR UniPathway; UPA00115; UER00409.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0017057; F:6-phosphogluconolactonase activity; IBA:GO_Central.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_01605; 6P_gluconolactonase; 1.
DR InterPro; IPR022528; 6-phosphogluconolactonase_YbhE.
DR InterPro; IPR019405; Lactonase_7-beta_prop.
DR InterPro; IPR011045; N2O_reductase_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF10282; Lactonase; 1.
DR SUPFAM; SSF50974; SSF50974; 2.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Glucose metabolism; Hydrolase; Reference proteome.
FT CHAIN 1..331
FT /note="6-phosphogluconolactonase"
FT /id="PRO_0000171139"
SQ SEQUENCE 331 AA; 36337 MW; 240B46DF97002DD5 CRC64;
MKQTVYTASP ESQQIHVWSL NHEGTLTLVQ VVDVPGQVQP MVVSPDKRYL YVGVRPEFRV
LAYRIAPDDG ALTFAAESAL PGSPTHISTD HHGRFVFVGS YNAGNVSVTR LQDGLPVELV
DVVEGLDGCH SANITPDNRT LWVPALKQDR ICLFTLSDDG HLVAQEPAEV NTVEGAGPRH
MVFHPNRQYA YCVNELNSSV DVWQLKNPHG EIECVQTLDM MPADFSDTRW AADIHITPDG
RHLYACDRTA SLITVFSVSE DGSVLSVEGF QPTEAQPRGF NIDNSGKYLI AAGQKSHHIA
VYEITGTQGL LTEKGRYAVG QGPMWVVVNA Y
