MRD1_ASPFU
ID MRD1_ASPFU Reviewed; 825 AA.
AC Q4WJT7;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Multiple RNA-binding domain-containing protein 1;
GN Name=mrd1; ORFNames=AFUA_1G04840;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Involved in pre-rRNA processing. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RRM MRD1 family. {ECO:0000305}.
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DR EMBL; AAHF01000007; EAL88195.1; -; Genomic_DNA.
DR RefSeq; XP_750233.1; XM_745140.1.
DR AlphaFoldDB; Q4WJT7; -.
DR SMR; Q4WJT7; -.
DR STRING; 746128.CADAFUBP00000512; -.
DR PRIDE; Q4WJT7; -.
DR EnsemblFungi; EAL88195; EAL88195; AFUA_1G04840.
DR GeneID; 3507335; -.
DR KEGG; afm:AFUA_1G04840; -.
DR VEuPathDB; FungiDB:Afu1g04840; -.
DR eggNOG; KOG0110; Eukaryota.
DR HOGENOM; CLU_008479_0_0_1; -.
DR InParanoid; Q4WJT7; -.
DR OMA; TALIEYC; -.
DR OrthoDB; 1428854at2759; -.
DR Proteomes; UP000002530; Chromosome 1.
DR GO; GO:0030686; C:90S preribosome; IEA:EnsemblFungi.
DR GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0042134; F:rRNA primary transcript binding; IEA:EnsemblFungi.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0034462; P:small-subunit processome assembly; IEA:EnsemblFungi.
DR CDD; cd12568; RRM3_MRD1; 1.
DR Gene3D; 3.30.70.330; -; 5.
DR InterPro; IPR034482; Mrd1_RRM3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR Pfam; PF00076; RRM_1; 5.
DR SMART; SM00360; RRM; 5.
DR SMART; SM00361; RRM_1; 1.
DR SUPFAM; SSF54928; SSF54928; 3.
DR PROSITE; PS50102; RRM; 5.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding;
KW rRNA processing.
FT CHAIN 1..825
FT /note="Multiple RNA-binding domain-containing protein 1"
FT /id="PRO_0000081637"
FT DOMAIN 4..76
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 301..379
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 484..556
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 597..680
FT /note="RRM 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 702..779
FT /note="RRM 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 80..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 825 AA; 92395 MW; D7E75A56557141B9 CRC64;
MENTRVFVSG LPPTFTNDQL RMHFSSRFQI TDAHVLPKRR IGFVGFKSSE AAQQAASYFN
KTYVKMSKIS VEIAKPIDSE PVKKAEKHRK GSTSNDSTAG KALKRKRDGD NTQKDPQLQE
YLSVIERPSK TKTWANGDDF LNTIQNQPAT SELREEQRDD TSEKVEEHSH KQRKKPRVDD
VPKAAHDREP EPMVLDKTEE EHERANADGQ VEAIPPTQEE AEPVSDADWL RSKTSRLLGL
LDEDEQAEFD STAQRKPDPS SEPETVSKAG AQHSDDDKAA VESSVEEEEV DTNIEHIRLS
SRLFVRNLPY DASESDLEPV FSKFGKIEEI HVAFDTRSTT SKGFAYVQYI EPDAAVQAYK
ELDGKHFQGR LMHILPATAK KTYKIDEHEL SKLPLKKQKQ IKRKLEASSS TFSWNSLYMN
TDAVMSSVAE RLGVSKADLL DPTSADAAVK QAHAETHVIQ ETKAYFTANG VNLDAFKQRE
RGNTAILVKN FSYGVKVDDL RKLFEPYGQI TRLLMPPSGT IAIVEFARPD EAQKAFKGLA
YRKVGDSILF LEKAPANLFD ATTAPQTSVL ETKAVSQGFS TADTFAAEDG DEPVVTSTLF
VKNLNFSTTN ERFTEVFKPL DGFVSARIKT KPDPKRPGKT LSMGFGFVDF RTKAQAQAAL
AAMDGYKLDQ HELVVRASNK AMDAAEERRR EDTAKKIAAR RTKIIIKNLP FQATKKDVRS
LFGAYGQLRS VRVPKKFDRS ARGFGFADFV SAREAENAMD ALKNTHLLGR RLVLEFANEE
AVDPEQEIEQ IEKKVGEQLD RVKLQKLTGT GRKKFTVGAQ EDEEA
