ID   MRD1_CANAL              Reviewed;         841 AA.
AC   Q5AJS6; A0A1D8PJC4; Q5AJE7;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Multiple RNA-binding domain-containing protein 1;
GN   Name=MRD1; OrderedLocusNames=CAALFM_C302020WA;
GN   ORFNames=CaO19.1646, CaO19.9215;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in pre-rRNA processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRM MRD1 family. {ECO:0000305}.
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DR   EMBL; CP017625; AOW28240.1; -; Genomic_DNA.
DR   RefSeq; XP_721723.2; XM_716630.2.
DR   AlphaFoldDB; Q5AJS6; -.
DR   SMR; Q5AJS6; -.
DR   STRING; 237561.Q5AJS6; -.
DR   PRIDE; Q5AJS6; -.
DR   GeneID; 3636592; -.
DR   KEGG; cal:CAALFM_C302020WA; -.
DR   CGD; CAL0000192627; orf19.9215.
DR   VEuPathDB; FungiDB:C3_02020W_A; -.
DR   eggNOG; KOG0110; Eukaryota.
DR   HOGENOM; CLU_008479_0_0_1; -.
DR   InParanoid; Q5AJS6; -.
DR   OrthoDB; 1428854at2759; -.
DR   PRO; PR:Q5AJS6; -.
DR   Proteomes; UP000000559; Chromosome 3.
DR   GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12568; RRM3_MRD1; 1.
DR   Gene3D; 3.30.70.330; -; 5.
DR   InterPro; IPR034482; Mrd1_RRM3.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR003954; RRM_dom_euk.
DR   Pfam; PF00076; RRM_1; 5.
DR   SMART; SM00360; RRM; 5.
DR   SMART; SM00361; RRM_1; 2.
DR   SUPFAM; SSF54928; SSF54928; 3.
DR   PROSITE; PS50102; RRM; 5.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..841
FT                   /note="Multiple RNA-binding domain-containing protein 1"
FT                   /id="PRO_0000081638"
FT   DOMAIN          2..79
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          310..388
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          493..565
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          617..700
FT                   /note="RRM 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          717..794
FT                   /note="RRM 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          194..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..227
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   841 AA;  94935 MW;  C5633671A83B0C99 CRC64;
     MSRLIVKGLP KYYTEEKLRE FFSKQGDVTD VKLMKKRNGE SRKFAFIGYK SADAAERAVK
     YFNKSFIDTA RIEVEFAKTF SDPTVPLSFK EKRKREEQKL KDEQERLLEQ ELRAQAKKQK
     TKSTSEIDDE IASNPKLREY MEVMKPSHQV KSWANDTIAD GSGGPSVQDL ENALNGNNES
     PVDKSNIEVV NTVEDASDDE YNDFKELSNK HGENEDEEEE EEMMSLGDLP TNEENKDKNE
     SGENLAANEN ISDLEWLKSR STRIKENGEV PEIVPEVKEV NEVTEATQQS DNEPEMTPEE
     QIAHKIEETG RLFIRNISYE ASEEDFRSLF SQYGALEEVH IAIDTRTGKS KGFLYVQFLK
     KEDATRAYRS LDKQIFQGRL LHILPADKKK DHRLDEFDLK NLPLKKQREL KKKAQAAKTQ
     FSWNSLYMNS DAVLESVASK LGVTKSQLID PENSSSAVKQ ALAEAHVIGD VRKYFEDRGV
     DLTSFDKKER DDKIILVKNF PFGTTIDEIG ELFSAYGQLK RMLMPPAGTI AIIEFRDAPS
     ARAAFSKLAY KRFKSSILYL EKGPKDLFTR EPTTNEVATI PEQQQNEHAV EAKISANEIL
     GESKEDDEIE SVQGPTVAVF VKNLNFATTV QALSDLFKPL PGFVVATVKT KPDPKNSGKT
     LSMGFGFVEF RTKEQANVAI STLDGHVLDG HKLQLKLSHK QGTGTSASSI KKSGKSSKII
     IKNLPFEATR KDLLELFGAF GQLKSVRVPK KFDQSARGFA FVEFNLMKEA ETAMSQLEGV
     HLLGRRLVMQ YAEQDAENAE VEIERMTKKV KKQVATQNLA AARLAGKGKI ELEEKDEEDF
     D