ID   MRD1_CRYNJ              Reviewed;         769 AA.
AC   P0CR16; Q55WN0; Q5KJL5;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Multiple RNA-binding domain-containing protein 1;
GN   Name=MRD1; OrderedLocusNames=CNC06110;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in pre-rRNA processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRM MRD1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE017343; AAW42566.1; -; Genomic_DNA.
DR   RefSeq; XP_569873.1; XM_569873.1.
DR   AlphaFoldDB; P0CR16; -.
DR   SMR; P0CR16; -.
DR   STRING; 5207.AAW42566; -.
DR   PaxDb; P0CR16; -.
DR   EnsemblFungi; AAW42566; AAW42566; CNC06110.
DR   eggNOG; KOG0110; Eukaryota.
DR   HOGENOM; CLU_008479_0_0_1; -.
DR   InParanoid; P0CR16; -.
DR   OMA; QMFRKFG; -.
DR   OrthoDB; 1428854at2759; -.
DR   Proteomes; UP000002149; Chromosome 3.
DR   GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12568; RRM3_MRD1; 1.
DR   Gene3D; 3.30.70.330; -; 5.
DR   InterPro; IPR034482; Mrd1_RRM3.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 4.
DR   SMART; SM00360; RRM; 5.
DR   SUPFAM; SSF54928; SSF54928; 4.
DR   PROSITE; PS50102; RRM; 5.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..769
FT                   /note="Multiple RNA-binding domain-containing protein 1"
FT                   /id="PRO_0000081640"
FT   DOMAIN          24..102
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          221..299
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          417..489
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          535..618
FT                   /note="RRM 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          640..723
FT                   /note="RRM 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          105..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          151..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          617..637
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          740..769
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..138
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..180
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        617..635
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   769 AA;  84551 MW;  1F5F16724201194A CRC64;
     MRCRSVALVW REWKWRGVGD KRQSRLIFLN LPSTLNPDTF RKTLLSPATL KSTTITDTKL
     VPKRRFAFVG YKDAEEAQKV KEWFDGTYAF GGGKVKVDFV KDEPLKTGDK LNRGEKSKEK
     RSKEGRDNVQ EKQEPNKRLQ EFMSVMKGVD PAMASPEAST STAEGTKKEK SVKGKEKSEE
     PEEAEADDDD AAWLRRRQAA LEGEPSTPQL SADEQLILST SRLFVRNLAF ITTSESLSSH
     FSTYGRIDEC HLPVSQTTGE PLGTAFLQFH NAEDALAAYK ALDKTIFQGR LLHVLPGRAK
     PGQEGAAAGS GVVDGKVLGK RDEGRGEVKS KVDAKRKQES AKGVNWASLY MNSDAVAASV
     ADRMGISKSE LLNADSGNSA VKLALAETTV IEETKKYFEE AGIVLESLQP RVPRSQTTIL
     VKNIPYGTSI QSLTDLFAPH GKLTRVLLPP AGTLGVVEFE NHMDAGRAFK ALAYRRLGNA
     VLYLEKGPVG MFKSETAPGV GPISTEQKRE EEAKALAEKV ESLPEQPDPT DEAGSTLFLK
     GLNFTTTTPH LQTVLSHIPG FSFARVQMKP DPKRPGEKLS MGYGFVGFKT KEAATKALKA
     LEGFEIDGKS LEVKFAQRGA EDDRETKKGG DAEGGKTKST KVLVKNLPFE ATKKDVRELF
     SAYGQLKSLR LPRKAVPTST GAQSTRGFAF LEFTTHTEAA RAMEALKHTH LLGRHLVLQW
     ANEGEEVDIK GLREKVKGEV RGMEDGGDRK RRKLDFKGGK EDEMDGLEV