MRD1_DICDI
ID MRD1_DICDI Reviewed; 895 AA.
AC Q54PB2;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Multiple RNA-binding domain-containing protein 1;
DE AltName: Full=RNA-binding motif protein 19 homolog;
DE AltName: Full=RNA-binding protein 19 homolog;
GN Name=mrd1; Synonyms=rbm19; ORFNames=DDB_G0284663;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RRM MRD1 family. {ECO:0000305}.
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DR EMBL; AAFI02000070; EAL65101.1; -; Genomic_DNA.
DR RefSeq; XP_638463.1; XM_633371.1.
DR AlphaFoldDB; Q54PB2; -.
DR SMR; Q54PB2; -.
DR STRING; 44689.DDB0233347; -.
DR PaxDb; Q54PB2; -.
DR PRIDE; Q54PB2; -.
DR EnsemblProtists; EAL65101; EAL65101; DDB_G0284663.
DR GeneID; 8624714; -.
DR KEGG; ddi:DDB_G0284663; -.
DR dictyBase; DDB_G0284663; mrd1.
DR eggNOG; KOG0110; Eukaryota.
DR HOGENOM; CLU_008479_0_0_1; -.
DR InParanoid; Q54PB2; -.
DR OMA; TALIEYC; -.
DR PhylomeDB; Q54PB2; -.
DR PRO; PR:Q54PB2; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005730; C:nucleolus; ISS:dictyBase.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; ISS:dictyBase.
DR GO; GO:0048255; P:mRNA stabilization; IBA:GO_Central.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISS:dictyBase.
DR Gene3D; 3.30.70.330; -; 5.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR Pfam; PF00076; RRM_1; 5.
DR SMART; SM00360; RRM; 5.
DR SMART; SM00361; RRM_1; 2.
DR SUPFAM; SSF54928; SSF54928; 5.
DR PROSITE; PS50102; RRM; 5.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..895
FT /note="Multiple RNA-binding domain-containing protein 1"
FT /id="PRO_0000327807"
FT DOMAIN 4..79
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 361..439
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 553..625
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 678..761
FT /note="RRM 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 795..872
FT /note="RRM 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 84..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 96..134
FT /evidence="ECO:0000255"
FT COILED 284..331
FT /evidence="ECO:0000255"
FT COMPBIAS 84..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..659
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 895 AA; 102101 MW; 2A938B21FA5AEE47 CRC64;
MSNTRICVKQ LPKHLTDKRF KEHFEKFGTV TDAKIIKKDG KSRLFGFIGF STEQSAKNAL
SLNGTFIDTS KIVVETATVA SETTENRPWS KYSIGSSSNK RLTEMEKEKE KKELKRKQDK
LEQQSNKKQK KSHTNSLLDA ELENDPEYQE FLNLVAPQAN RKVWENDDKE IGKINRGEEE
GEEGEENDNQ VEDGKLPFSG KKKIELDHGK NKDLLVFEDA DASDEEDLYE DMPTAPKKQN
KKDDVDSIIN EKKKKHDSSV SDLDWLSKFR SNNDEIIEKN QSIVYRDEEE SEEEDVNNKE
NKKDKMKIDD NKENKKEKKK DKKKNKKDND NDGDDDESKI KPIKYFEHDY TKEDEDVGES
GRIFVRNLSY STKEEDLEKV FSKFGKISEI HIPIDYDSKK SKGIAFILYL IPENAVQALN
DMDGKVFQGR LIHVLPGKAA PAKQFSENKD NNNNGAEGGS SSFKAEKEQK QKTTSGSTHN
WNALFMRSDA IVSSLAERYK MTQGQLLDPN QMDLAVRMTL METHVINETK KFLEDQGVII
QDIGNKGSKR SNTVLLVKNI PFKTQEHELH ELFSKFGELS RVVLSPARTI ALIEYIHPNE
AKVGFKNLAY SKFHHVPLYL EWAPEGVFKL PAPPKEIKKS EKSEKSSDSS NDKKEVESTT
KTAATTTTTK KGTDNNTQFV YIKNLNWKTT NETLVGKFKS LKDYVNVNIA TKANPKNPSE
RLPCGFGFIE FSSKQGAYEC IKKLNGSSID GYEISLKLSD KNETNVQEIN KRRELPENSK
QSIKSNGGQP NKPSSKIIIK NLPFESTIKE IRKLFTAYGE IQSVRIPKKP NGGHRGFGFV
EFLTEEEAKN AMEALGNSHF YGRHLVLQYA EQDKNIDELR EKANLDYEKI KNSTF
