ID   MRD1_NEUCR              Reviewed;         827 AA.
AC   Q7SG09; Q6MV47;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Multiple RNA-binding domain-containing protein 1;
GN   Name=mrd-1; ORFNames=53H1.110, NCU02611;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in pre-rRNA processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRM MRD1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAE76453.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; BX842633; CAE76453.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CM002236; EAA35778.1; -; Genomic_DNA.
DR   RefSeq; XP_965014.1; XM_959921.2.
DR   AlphaFoldDB; Q7SG09; -.
DR   SMR; Q7SG09; -.
DR   STRING; 5141.EFNCRP00000002082; -.
DR   PRIDE; Q7SG09; -.
DR   EnsemblFungi; EAA35778; EAA35778; NCU02611.
DR   GeneID; 3881154; -.
DR   KEGG; ncr:NCU02611; -.
DR   VEuPathDB; FungiDB:NCU02611; -.
DR   HOGENOM; CLU_008479_0_0_1; -.
DR   InParanoid; Q7SG09; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0030686; C:90S preribosome; IEA:EnsemblFungi.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0042134; F:rRNA primary transcript binding; IEA:EnsemblFungi.
DR   GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0034462; P:small-subunit processome assembly; IEA:EnsemblFungi.
DR   CDD; cd12568; RRM3_MRD1; 1.
DR   Gene3D; 3.30.70.330; -; 5.
DR   InterPro; IPR034482; Mrd1_RRM3.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 4.
DR   SMART; SM00360; RRM; 5.
DR   SUPFAM; SSF54928; SSF54928; 4.
DR   PROSITE; PS50102; RRM; 4.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..827
FT                   /note="Multiple RNA-binding domain-containing protein 1"
FT                   /id="PRO_0000081643"
FT   DOMAIN          5..78
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          308..384
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          489..560
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          599..682
FT                   /note="RRM 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          704..781
FT                   /note="RRM 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          77..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        261..275
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        277..292
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   827 AA;  90408 MW;  30B2988878E07A3F CRC64;
     MESSSRIFVK NLPPTITEAE FRKHFSAEGR QVTDVKLIPA RHIGFVGYKS AEDAARAVKY
     FNRSFIRMSR ISVDIAKPIA DSKPQHKSPS KGSSKDADPK NAPKVLPPNT KVTAAAVPKV
     EAAPDAPKRK LDVLDEADPK LQEYLDVMGA HPSKKMRNAE GLPTTVDEVL APAVPAGLED
     GESDDEYEDI PSRTHNQSHT ADQEMVDAPL AASAEPSESA PPVSLDATDD DWLRSRTNRL
     LDLVDPEDAA FALRPAASGS AAVSVPSTSV ENTASAKPEE HPAEDSREMA ATSTHDPESA
     ISLIEKTSRL FLRNLSYTVT EDDVREHFAK FGILVEVHVP LDSKGHSKGF AMIRYEKPAS
     ALAAFQTDGT VFQGRIVHIL PAAAKRENKL DEFALSKLPL KKQQLLRKKA EAASSTFNWN
     SLFMSQDAVN TAMAERLGVS KAELLDPTDA SAAVKQAVAE TTVIQEAKQY FAANGVNIEA
     FKTQQRGDTT ILVKNIKNTT IEELRTLFEE HGTVLRVLMP PSGTIAIVQF AQPVQCRTAF
     ARKAYSRFKD SVLFLEKGPK GLFTDNVAVP TDARPAGVQK PSVADLLERD DAEEQLETSS
     LFVRNLNFST TSQGLTDAFK HLDGFVQAKV KTKTDPKKPG QVLSMGFGFV AFRTKDQAQA
     ALKVMDGQVL DAHKISVKAS HRGLDAAEER RREDMAKKAA NQGTKLVVKN LPFEVTKKEV
     RTLFSAYGKL VALRIPKKFN QSSRGFAFAE FSTAKEALNA FNSLKDTHIL GRRLVIDFAQ
     AEDIDPEDQI AAMEKKTRAQ VNKVALQQLT GTGRAKVTIG DNDEDEV