MRD1_SCHPO
ID MRD1_SCHPO Reviewed; 833 AA.
AC O13620; Q9UTU1;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=Multiple RNA-binding domain-containing protein 1;
GN Name=mrd1; ORFNames=pi029, SPBP22H7.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=10620777;
RX DOI=10.1002/(sici)1097-0061(20000115)16:1<71::aid-yea505>3.0.co;2-5;
RA Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K.,
RA Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y.,
RA Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.;
RT "A 38 kb segment containing the cdc2 gene from the left arm of fission
RT yeast chromosome II: sequence analysis and characterization of the genomic
RT DNA and cDNAs encoded on the segment.";
RL Yeast 16:71-80(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 304-463, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
CC -!- FUNCTION: Involved in pre-rRNA processing. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10759889}.
CC -!- SIMILARITY: Belongs to the RRM MRD1 family. {ECO:0000305}.
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DR EMBL; AB004535; BAA21408.1; -; Genomic_DNA.
DR EMBL; CU329671; CAC37370.1; -; Genomic_DNA.
DR EMBL; AB028003; BAA87307.1; -; Genomic_DNA.
DR RefSeq; NP_595599.1; NM_001021494.2.
DR AlphaFoldDB; O13620; -.
DR SMR; O13620; -.
DR BioGRID; 277815; 3.
DR STRING; 4896.SPBP22H7.02c.1; -.
DR iPTMnet; O13620; -.
DR MaxQB; O13620; -.
DR PaxDb; O13620; -.
DR PRIDE; O13620; -.
DR EnsemblFungi; SPBP22H7.02c.1; SPBP22H7.02c.1:pep; SPBP22H7.02c.
DR GeneID; 2541303; -.
DR KEGG; spo:SPBP22H7.02c; -.
DR PomBase; SPBP22H7.02c; mrd1.
DR VEuPathDB; FungiDB:SPBP22H7.02c; -.
DR eggNOG; KOG0110; Eukaryota.
DR HOGENOM; CLU_008479_0_0_1; -.
DR InParanoid; O13620; -.
DR OMA; LEQVHMP; -.
DR PhylomeDB; O13620; -.
DR PRO; PR:O13620; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0030686; C:90S preribosome; ISO:PomBase.
DR GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0003723; F:RNA binding; ISO:PomBase.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISO:PomBase.
DR GO; GO:0034462; P:small-subunit processome assembly; ISO:PomBase.
DR CDD; cd12568; RRM3_MRD1; 1.
DR Gene3D; 3.30.70.330; -; 5.
DR InterPro; IPR034482; Mrd1_RRM3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 5.
DR SMART; SM00360; RRM; 5.
DR SUPFAM; SSF54928; SSF54928; 3.
DR PROSITE; PS50102; RRM; 5.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding;
KW rRNA processing.
FT CHAIN 1..833
FT /note="Multiple RNA-binding domain-containing protein 1"
FT /id="PRO_0000081644"
FT DOMAIN 2..83
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 323..401
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 506..578
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 619..702
FT /note="RRM 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 721..798
FT /note="RRM 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 160..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 93677 MW; 64FE767D43E02FE4 CRC64;
MSRIIIKNIP RYYDKEKLST YLKSLPQLDA EITDVSVAKT KEGVSRRFAF IGFKNEEDAD
KAIRYLNKSY VETSRIEVHR ALDYRSANEK LRPYSKYASK NIELKLQKKE KEEELRNLEE
EKAKKKKDAN LKRKFLDTLD PKAREFLKLS SSISNSRSWE NEEVFDTEIT NPVIPADEDD
DEYQDLPAAK RHEGDSIKST EHDSTLDSGV VIDGREKSSS ELHEEESEQA AEGDTAKNSG
TDAQAPLSDD EWLRLHRTRI KEKQPEEEVS VVGDELKSFD KENNDEHLER VTNDKIADAS
MLQKAENNVS EQERNIQLIS ETKRLFLRNL TYSCAEDDLK SLFGPFGQLE QVHMPIDKKT
NNPKGFAYID FHDADDAVRA YLELDAKPFQ GRLLHVLPAK ARSSILLDDY ALSKLPLKKQ
RELKRKNTAA SSTFSWNSLY MNADAVVTSL ASRLGVKKTD ILDPTSSDSA VKQALTETHV
IQETKNFFEE HGVDLDAFKN AARSDNVLLV KNFPYGTSAE ELTSLFSPFG ELGRILIPPA
GTIAIIEFLN APDCRQAFSK LAYTRIKSSI LYLEKAPRDV FTTSFKQSGK PELAQKVNAV
EATTSEKVGT EDIESLDTAT IYVKNLNFST KQEEFQKVFK PLEGYLSAVI RAKPDPKRPG
KYLSMGFGFV EFKDKASAVA AMHAMNGFVL DGHKLEIKLS HQGVDAAAEV RKQDSSKPKG
TKILIKNLPF EATKKDVQSL LGAYGQLRSV RVPKKFDRSA RGFAFAEFVT AREAANAMRA
LKNTHLLGRH LVLQYASNAT MDDMQHAIEK MAKEANAEAA APSITGKRLI ETD
