MRD1_USTMA
ID MRD1_USTMA Reviewed; 858 AA.
AC Q4PC17; A0A0D1E600;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Multiple RNA-binding domain-containing protein 1;
GN Name=MRD1; ORFNames=UMAG_02346;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in pre-rRNA processing. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RRM MRD1 family. {ECO:0000305}.
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DR EMBL; CM003144; KIS69825.1; -; Genomic_DNA.
DR RefSeq; XP_011388657.1; XM_011390355.1.
DR AlphaFoldDB; Q4PC17; -.
DR SMR; Q4PC17; -.
DR IntAct; Q4PC17; 1.
DR MINT; Q4PC17; -.
DR STRING; 5270.UM02346P0; -.
DR EnsemblFungi; KIS69825; KIS69825; UMAG_02346.
DR GeneID; 23563116; -.
DR KEGG; uma:UMAG_02346; -.
DR VEuPathDB; FungiDB:UMAG_02346; -.
DR eggNOG; KOG0110; Eukaryota.
DR HOGENOM; CLU_008479_0_0_1; -.
DR InParanoid; Q4PC17; -.
DR OMA; TALIEYC; -.
DR OrthoDB; 1428854at2759; -.
DR Proteomes; UP000000561; Chromosome 5.
DR GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR CDD; cd12568; RRM3_MRD1; 1.
DR Gene3D; 3.30.70.330; -; 5.
DR InterPro; IPR034482; Mrd1_RRM3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 5.
DR SMART; SM00360; RRM; 5.
DR SUPFAM; SSF54928; SSF54928; 4.
DR PROSITE; PS50102; RRM; 5.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding;
KW rRNA processing.
FT CHAIN 1..858
FT /note="Multiple RNA-binding domain-containing protein 1"
FT /id="PRO_0000081645"
FT DOMAIN 2..79
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 314..392
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 501..573
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 621..704
FT /note="RRM 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 719..796
FT /note="RRM 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 87..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..277
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 858 AA; 94006 MW; CF4FE97F4E3EA1C1 CRC64;
MSRLIVRGLP SYLTDARLRE HFSQKGAVTD VKLMRRPDGT SRKFGFVGYR SEQEAQQALD
YFNRTFIDTS RISIELAKKI GDEELVHQRE ERRNRRNAGA GPEGSASTSD ARKRKADKSD
TQQEEGSGKK KPKKGGAISF EEFMSVMQPK AKRKAWQNED ALPEQTMQDI VAPEEAIQKK
AARKALKKAD AAAAATATAE STAAQPDSGR EETPEPDAAA NDVGLTDEEY MRLRMKHRVG
TDLDTLEQSS SGPEFEQSDN EKDDDDAAAD SDPESEDEPI HDQGFECKQA EMQRKAQQAA
EKDQKLVDQI MESGRLFIRN LPFAASGDEI LAFFESFGTV KQVHIPLDKQ TKASKGLAFV
SFSDPAHALA AYRAKDGSTF QGRLLHLLPA VNKDALAETG SKKTATLKQA RAEQKKQDAT
KDFNWSMLYM SSDAVASSIA DRLGVNKSDI LNPGANGGAD NAAVRLALAE TRIIQETKEF
LAQQGINVDA FQGAKGPRSD TTILVKNIPY GTSAEEVEKL FGEHGEVDKV LIPPSGTIAV
VEMPVVNEAR LAFRAIAYKR FKGGILYLEK APVGLLTQHK VGEKVVKQAP IVGKSIDSSN
PSVDLDGPAG AGAGDEAVDG ATLYVKNLSF STTDERLTAF FHGLSDFAFA RIQTKPDPRR
PGARLSMGYG FVGFKSIDAA RTAQKAMDGK VLDAHTLVVT FARRNAEAST TSISSGGSTK
ILIKNLPFEA TKRDIRDLFS SQGQLKSVRL PKKFDNTTRG FGFVEYSTVR EAQSAMEALK
HTHLLGRHLV LQWSHLASST QQQVDMQRSK TKQHFVNTHD NAARADPSKR AKIKLNSAQI
SEAIKQAKRQ RDDVDDDE
