ID   MRD1_YARLI              Reviewed;         828 AA.
AC   Q6CEW9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Multiple RNA-binding domain-containing protein 1;
GN   Name=MRD1; OrderedLocusNames=YALI0B12276g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-rRNA processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRM MRD1 family. {ECO:0000305}.
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DR   EMBL; CR382128; CAG83044.1; -; Genomic_DNA.
DR   RefSeq; XP_500793.1; XM_500793.1.
DR   AlphaFoldDB; Q6CEW9; -.
DR   SMR; Q6CEW9; -.
DR   STRING; 4952.CAG83044; -.
DR   EnsemblFungi; CAG83044; CAG83044; YALI0_B12276g.
DR   GeneID; 2907128; -.
DR   KEGG; yli:YALI0B12276g; -.
DR   VEuPathDB; FungiDB:YALI0_B12276g; -.
DR   HOGENOM; CLU_008479_0_0_1; -.
DR   InParanoid; Q6CEW9; -.
DR   OMA; TALIEYC; -.
DR   Proteomes; UP000001300; Chromosome B.
DR   GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.330; -; 5.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 5.
DR   SMART; SM00360; RRM; 5.
DR   SUPFAM; SSF54928; SSF54928; 3.
DR   PROSITE; PS50102; RRM; 5.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..828
FT                   /note="Multiple RNA-binding domain-containing protein 1"
FT                   /id="PRO_0000081646"
FT   DOMAIN          2..89
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          301..379
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          485..557
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          605..688
FT                   /note="RRM 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          703..780
FT                   /note="RRM 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          97..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          166..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..229
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..274
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   828 AA;  92677 MW;  1CAF1783463649DB CRC64;
     MSRLIVKNLP PYLDEAGLKK HFSTVKDPKS AGFAPSDITD VKVVRARDGK TRRFGFVGFR
     SDETAEAAVK YFDTSFINST KISVAVAMTF TDPNVPLSSR ERKRQAAQRA REDAEDDREA
     KKARYLEKPM TIDDINGLGN ASDPRLADYL DAMQVRSNAK TWANNDAGAV ANEPQVIQST
     ASDDEYDEFT GKGDDEIDED EDEEEESENK KDDDNEEAEE DEEDPVIEDG LAADPGVSDM
     DWLRQRQTRI KEGEPEEDRE NRHTESKSEG KKGKGNAPKA ATPVDEEPSE DPTIVSIRKT
     GRLFLRNLLY TAKEEDFRQL FSQYGELEEV HLPINTKTGQ CKGFAHVQFE DPENAIAAYE
     AQDGKIFQGR LLHILPGKPK KDYNRLDEHD LKNLPLKKQQ ELKRKAEAAK QQFSWNSLYM
     NQDAVMESVA KSMGIKKSEL IDPDSSDAAV KQALAEATVI GDVKSYFEKM GVDLASFDNK
     DRDDRVILVK NFPFGTTQPE IAEMFSEYGD LYKVMMPPAG TIAIVIFKHI PDARAAFAKL
     AFRRFKTSIL YLEKGPKNLL PNEKMESDEV EHVKQDKIVT IEDKLSASDV MDTGSNDERP
     ATASTSVFVK NLNFKTTSRV LTDAFKALDG FLVAQVKMKP DSKNKGKFLS MGFGFVEFSS
     KEAAEIAQKA MDGHVLDGHK LQLKISNRGQ DEETTETKKA IDSKILIKNL PFEATKKDVQ
     KLFGAFGSLK TVRVPKKFNS ESRGFAFAEY VSAKEAEHAM SALQGTHLLG RRLVLQYAQA
     DASNAEEEIE RMQATVSKQA AQRSFADMKL AGEGKRRVDL EGEDEEEF