MRE11_NEUCR
ID MRE11_NEUCR Reviewed; 739 AA.
AC Q9C291; O74114; Q7RVZ7;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 3.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=Double-strand break repair protein mus-23;
DE AltName: Full=Recombinational repair protein mus-23;
GN Name=mus-23; ORFNames=B11O9.50, NCU08730;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9393441; DOI=10.1007/s004380050587;
RA Watanabe K., Sakuraba Y., Inoue H.;
RT "Genetic and molecular characterization of Neurospora crassa mus-23: a gene
RT involved in recombinational repair.";
RL Mol. Gen. Genet. 256:436-445(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Involved in DNA double-strand break repair (DSBR). Possesses
CC single-strand endonuclease activity and double-strand-specific 3'-5'
CC exonuclease activity. Also involved in meiotic DSB processing (By
CC similarity). {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC -!- SUBUNIT: Forms a complex with RAD50. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MRE11/RAD32 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA32417.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAC28562.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAC28562.2; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=EAA34355.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL513409; CAC28562.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AB002530; BAA32417.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CM002237; EAA34355.2; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_963591.2; XM_958498.3.
DR AlphaFoldDB; Q9C291; -.
DR SMR; Q9C291; -.
DR STRING; 5141.EFNCRP00000008604; -.
DR PRIDE; Q9C291; -.
DR EnsemblFungi; EAA34355; EAA34355; NCU08730.
DR GeneID; 3879754; -.
DR KEGG; ncr:NCU08730; -.
DR HOGENOM; CLU_009535_1_1_1; -.
DR InParanoid; Q9C291; -.
DR Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR GO; GO:0030870; C:Mre11 complex; IBA:GO_Central.
DR GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR GO; GO:0008296; F:3'-5'-exodeoxyribonuclease activity; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0000014; F:single-stranded DNA endodeoxyribonuclease activity; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IBA:GO_Central.
DR GO; GO:0042138; P:meiotic DNA double-strand break formation; IBA:GO_Central.
DR GO; GO:0097552; P:mitochondrial double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; IBA:GO_Central.
DR GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IBA:GO_Central.
DR GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
DR CDD; cd00840; MPP_Mre11_N; 1.
DR Gene3D; 3.30.110.110; -; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR003701; Mre11.
DR InterPro; IPR038487; Mre11_capping_dom.
DR InterPro; IPR007281; Mre11_DNA-bd.
DR InterPro; IPR041796; Mre11_N.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF04152; Mre11_DNA_bind; 1.
DR PIRSF; PIRSF000882; DSB_repair_MRE11; 1.
DR SMART; SM01347; Mre11_DNA_bind; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
DR TIGRFAMs; TIGR00583; mre11; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Endonuclease; Exonuclease; Hydrolase; Manganese;
KW Meiosis; Nuclease; Nucleus; Reference proteome.
FT CHAIN 1..739
FT /note="Double-strand break repair protein mus-23"
FT /id="PRO_0000138682"
FT REGION 516..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..684
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 124
FT /note="Proton donor"
FT /evidence="ECO:0000250"
SQ SEQUENCE 739 AA; 83544 MW; 433E8374BEE4113E CRC64;
MPRSEADTIR ILVSTDNHVG YAERHPVRKD DSWRTFDEIM QIAKKQDVDM VLLGGDLFHE
NKPSRKSMYQ VMRSLRKHCL GMKPCELEFL SDAAEVFEGA FPFVNYEDPD INVAIPVFSI
HGNHDDPSGD GHYCSLDLLQ AAGLVNYFGR VPEADNIHVK PILLQKGRTK MALYGLSNVR
DERMHRTFRD NKVRFYRPNQ QKNDWFNLLA LHQNHYAHTR TSYVAENMLP DFMDLVIWGH
EHECLIDPVR NPETGFHVMQ PGSSVATSLV PGEAVPKHVA ILNITGRKFE VDKIPLKTVR
PFVTREIVLA SDKRFKGLDK QNNRHEITKR LMVIVNEMIE EANAEWRAVH AEDDDMDEDM
EPPLPLVRLK VDYTAPDGAR YEVENPHRFS NRFTGKVANH NDVVRFHCNT KGKKNVATAP
GVREDIAEIL ESADTIKVDN LVQEFFAQQS LKILPQAPFS DAVNQFVSKD DKHAVEMFVI
ESLSTQVKEL LQLDDDKIVD LDAHIQDFRQ VMEKSFDAGQ HKQAQRTKRF KRKPDGWDSD
LDGHWINQPQ ALEDIPAEVE PKGNDRPTKR VPTSGVTFSD EDEDMDMDNQ PVPIRAAPKR
GAAAKTTAAA KKAAPGKKAA PAKKAAPAKK AAPAKKAPAR GRKKKTPFVD SDEEEEEDYP
EDDDEEEEEA DEEEEDVIME DDEEDPPAPP PKPKATSRVA STRASARATP VRATPARATQ
ARLRLRRPPK PGLLARRLG
