ID   MREB_HAEIN              Reviewed;         351 AA.
AC   P44474;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Cell shape-determining protein MreB {ECO:0000255|HAMAP-Rule:MF_02207};
GN   Name=mreB {ECO:0000255|HAMAP-Rule:MF_02207}; OrderedLocusNames=HI_0037;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Forms membrane-associated dynamic filaments that are
CC       essential for cell shape determination. Acts by regulating cell wall
CC       synthesis and cell elongation, and thus cell shape. A feedback loop
CC       between cell geometry and MreB localization may maintain elongated cell
CC       shape by targeting cell wall growth to regions of negative cell wall
CC       curvature. {ECO:0000255|HAMAP-Rule:MF_02207}.
CC   -!- SUBUNIT: Forms polymers. {ECO:0000255|HAMAP-Rule:MF_02207}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02207}.
CC       Note=Membrane-associated. {ECO:0000255|HAMAP-Rule:MF_02207}.
CC   -!- SIMILARITY: Belongs to the FtsA/MreB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02207, ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC21715.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L42023; AAC21715.1; ALT_INIT; Genomic_DNA.
DR   PIR; E64044; E64044.
DR   RefSeq; NP_438210.2; NC_000907.1.
DR   RefSeq; WP_005657804.1; NC_000907.1.
DR   AlphaFoldDB; P44474; -.
DR   SMR; P44474; -.
DR   STRING; 71421.HI_0037; -.
DR   EnsemblBacteria; AAC21715; AAC21715; HI_0037.
DR   KEGG; hin:HI_0037; -.
DR   PATRIC; fig|71421.8.peg.37; -.
DR   eggNOG; COG1077; Bacteria.
DR   HOGENOM; CLU_052037_0_0_6; -.
DR   PhylomeDB; P44474; -.
DR   BioCyc; HINF71421:G1GJ1-37-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000902; P:cell morphogenesis; IEA:InterPro.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-UniRule.
DR   CDD; cd10225; MreB_like; 1.
DR   HAMAP; MF_02207; MreB; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR004753; MreB.
DR   PRINTS; PR01652; SHAPEPROTEIN.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR00904; mreB; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell shape; Cytoplasm; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..351
FT                   /note="Cell shape-determining protein MreB"
FT                   /id="PRO_0000062761"
FT   BINDING         20..22
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02207"
FT   BINDING         169..171
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02207"
FT   BINDING         217..220
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02207"
FT   BINDING         299..302
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02207"
SQ   SEQUENCE   351 AA;  37616 MW;  D97CA0686403B279 CRC64;
     MLFKKIRGLF SNDLSIDLGT ANTLIYVKRQ GIVLDEPSVV AIRQDRVGTL KSIAAVGKEA
     KLMLGRTPKS IVAIRPMKDG VIADFFVTEK MLQYFIKQVH SGNFMRPSPR VLVCVPAGAT
     QVERRAIKES AIGAGAREVY LIEEPMAAAI GAKLPVSTAV GSMVIDIGGG TTEVAVISLN
     GIVYSSSVRI GGDRFDEAII SYVRRTFGSV IGEPTAERIK QEIGSAYIQE GDEIKEMEVH
     GHNLAEGAPR SFTLTSRDVL EAIQQPLNGI VAAVRTALEE CQPEHAADIF ERGMVLTGGG
     ALLRNIDILL SKESGVPVII AEDPLTCVAR GGGEALEMID MHGGDIFSDE I