MRED_BACSU
ID MRED_BACSU Reviewed; 172 AA.
AC Q01467;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Rod shape-determining protein MreD;
GN Name=mreD; Synonyms=rodB; OrderedLocusNames=BSU28010;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=1400225; DOI=10.1128/jb.174.21.6729-6742.1992;
RA Varley A.W., Stewart G.C.;
RT "The divIVB region of the Bacillus subtilis chromosome encodes homologs of
RT Escherichia coli septum placement (minCD) and cell shape (mreBCD)
RT determinants.";
RL J. Bacteriol. 174:6729-6742(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1400224; DOI=10.1128/jb.174.21.6717-6728.1992;
RA Levin P.A., Margolis P.S., Setlow P., Losick R., Sun D.;
RT "Identification of Bacillus subtilis genes for septum placement and shape
RT determination.";
RL J. Bacteriol. 174:6717-6728(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- FUNCTION: Involved in formation of the rod shape of the cell. May also
CC contribute to regulation of formation of penicillin-binding proteins
CC (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q01467; P42954: tagH; NbExp=3; IntAct=EBI-5246853, EBI-6401700;
CC Q01467; O34753: tagO; NbExp=3; IntAct=EBI-5246853, EBI-6401688;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the MreD family. {ECO:0000305}.
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DR EMBL; M95582; AAA22607.1; -; Genomic_DNA.
DR EMBL; M96343; AAA22399.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14761.1; -; Genomic_DNA.
DR PIR; E45239; E45239.
DR RefSeq; NP_390679.1; NC_000964.3.
DR RefSeq; WP_004398811.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; Q01467; -.
DR SMR; Q01467; -.
DR IntAct; Q01467; 21.
DR STRING; 224308.BSU28010; -.
DR TCDB; 9.B.157.1.1; the cell shape-determining mrebcd (mrebcd) family.
DR PaxDb; Q01467; -.
DR PRIDE; Q01467; -.
DR EnsemblBacteria; CAB14761; CAB14761; BSU_28010.
DR GeneID; 936183; -.
DR KEGG; bsu:BSU28010; -.
DR PATRIC; fig|224308.179.peg.3043; -.
DR eggNOG; COG2891; Bacteria.
DR OMA; VCVLEFY; -.
DR PhylomeDB; Q01467; -.
DR BioCyc; BSUB:BSU28010-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR InterPro; IPR007227; Cell_shape_determining_MreD.
DR Pfam; PF04093; MreD; 1.
DR TIGRFAMs; TIGR03426; shape_MreD; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cell shape; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..172
FT /note="Rod shape-determining protein MreD"
FT /id="PRO_0000062769"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 172 AA; 19816 MW; 1E533A1EA27A800E CRC64;
MKRFLLPFVM MLVFSAESIF TDLVHFPFVT DDQVLAPRFL MLVLIFMSAF INQKHAMIYG
FIFGFLYDMN YTSLLGVYMF GFAGLCYLAS KAFKVLHTNA FVVILIAVLA VCLLEFYVFG
IQSLIHKDIM TFNGFVLDRF IPTILLNIAA ALILVLPFRL FFMSLKKELR DE
