ID   MRED_HAEIN              Reviewed;         162 AA.
AC   P44476;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Rod shape-determining protein MreD;
GN   Name=mreD; OrderedLocusNames=HI_0039;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Involved in formation of the rod shape of the cell. May also
CC       contribute to regulation of formation of penicillin-binding proteins
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MreD family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L42023; AAC21717.1; -; Genomic_DNA.
DR   PIR; G64044; G64044.
DR   RefSeq; NP_438212.1; NC_000907.1.
DR   RefSeq; WP_005657800.1; NC_000907.1.
DR   AlphaFoldDB; P44476; -.
DR   STRING; 71421.HI_0039; -.
DR   EnsemblBacteria; AAC21717; AAC21717; HI_0039.
DR   KEGG; hin:HI_0039; -.
DR   PATRIC; fig|71421.8.peg.39; -.
DR   eggNOG; COG2891; Bacteria.
DR   HOGENOM; CLU_119315_0_0_6; -.
DR   OMA; YWAMALP; -.
DR   PhylomeDB; P44476; -.
DR   BioCyc; HINF71421:G1GJ1-39-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR   InterPro; IPR007227; Cell_shape_determining_MreD.
DR   InterPro; IPR026034; MreD_proteobac.
DR   PANTHER; PTHR37484; PTHR37484; 1.
DR   Pfam; PF04093; MreD; 1.
DR   PIRSF; PIRSF018472; MreD_proteobac; 1.
DR   TIGRFAMs; TIGR03426; shape_MreD; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Cell shape; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..162
FT                   /note="Rod shape-determining protein MreD"
FT                   /id="PRO_0000062773"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   162 AA;  18965 MW;  3985BA4EA37BAAE6 CRC64;
     MQTRFILQWF TILSFFVIAF VLELAPWPVG FQMLKPAWLV LVLLYWVLAI PNKVSIGWSF
     LLGLTWDLIL GSTLGVHALV LSTSMYIIAK NYLILRNLSL WFQSLLVVLF VFIIRLLIFL
     VEFSLHTAFF HWQAILGAFA SGLLWPWVFL LMRKIRRKVK LH