ID   MRED_STRR6              Reviewed;         164 AA.
AC   Q8DMY3;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Cell shape-determining protein MreD;
GN   Name=mreD; OrderedLocusNames=spr2022;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
RN   [2]
RP   SUBUNIT.
RC   STRAIN=R6 / R704;
RX   PubMed=28710862; DOI=10.1111/mmi.13748;
RA   Stamsaas G.A., Straume D., Ruud Winther A., Kjos M., Frantzen C.A.,
RA   Haavarstein L.S.;
RT   "Identification of EloR (Spr1851) as a regulator of cell elongation in
RT   Streptococcus pneumoniae.";
RL   Mol. Microbiol. 105:954-967(2017).
CC   -!- FUNCTION: Involved in formation and maintenance of cell shape, probably
CC       part of the elongasome which synthesizes peripheral peptidogylcan (PG).
CC       {ECO:0000305|PubMed:28710862}.
CC   -!- SUBUNIT: Interacts with MreC in the elongasome; interaction requires
CC       the 90 C-terminal residues of MreC. {ECO:0000269|PubMed:28710862}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the MreD family. {ECO:0000305}.
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DR   EMBL; AE007317; AAL00824.1; -; Genomic_DNA.
DR   PIR; C98124; C98124.
DR   PIR; H95258; H95258.
DR   RefSeq; NP_359613.1; NC_003098.1.
DR   RefSeq; WP_001249454.1; NC_003098.1.
DR   AlphaFoldDB; Q8DMY3; -.
DR   STRING; 171101.spr2022; -.
DR   EnsemblBacteria; AAL00824; AAL00824; spr2022.
DR   GeneID; 60234265; -.
DR   GeneID; 66807288; -.
DR   KEGG; spr:spr2022; -.
DR   PATRIC; fig|171101.6.peg.2188; -.
DR   eggNOG; COG2891; Bacteria.
DR   HOGENOM; CLU_121959_2_0_9; -.
DR   OMA; VCVLEFY; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   InterPro; IPR007227; Cell_shape_determining_MreD.
DR   Pfam; PF04093; MreD; 1.
DR   TIGRFAMs; TIGR03426; shape_MreD; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Cell shape; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..164
FT                   /note="Cell shape-determining protein MreD"
FT                   /id="PRO_0000454548"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   164 AA;  19324 MW;  1080F41C8643E366 CRC64;
     MRQLKRVGVF LLLPFFVLID AHISQLLGSF FPHVHLASHF LFLFLLFETI EVSEYLYLVY
     CFVIGLVYDV YFFHLIGITT LLFILLGAFL HKLNSVILLN RWTRMLAMIV LTFLFEMGSY
     LLAFMVGLTV DSMSIFIVYS LVPTMILNFL WITVFQFIFE KYYL