ID   MREG_XENTR              Reviewed;         196 AA.
AC   Q0P4L7;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Melanoregulin;
GN   Name=mreg;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Oviduct;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably functions as cargo-recognition protein that couples
CC       cytoplasmic vesicles to the transport machinery. Contributes to
CC       retrograde melanosome transport from the cell periphery to the center.
CC       Overexpression causes accumulation of late endosomes and/or lysosomes
CC       at the microtubule organising center (MTOC) at the center of the cell.
CC       Probably binds cholesterol and requires the presence of cholesterol in
CC       membranes to function in microtubule-mediated retrograde organelle
CC       transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol
CC       4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol
CC       3,5-bisphosphate. {ECO:0000250|UniProtKB:Q6NVG5}.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane
CC       {ECO:0000250|UniProtKB:Q6NVG5}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q6NVG5}. Melanosome membrane
CC       {ECO:0000250|UniProtKB:Q6NVG5}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:Q6NVG5}. Lysosome membrane
CC       {ECO:0000250|UniProtKB:Q6NVG5}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:Q6NVG5}. Cytoplasmic vesicle membrane
CC       {ECO:0000250|UniProtKB:Q6NVG5}.
CC   -!- SIMILARITY: Belongs to the melanoregulin family. {ECO:0000305}.
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DR   EMBL; BC122004; AAI22005.1; -; mRNA.
DR   RefSeq; NP_001016432.1; NM_001016432.2.
DR   AlphaFoldDB; Q0P4L7; -.
DR   SMR; Q0P4L7; -.
DR   PaxDb; Q0P4L7; -.
DR   PRIDE; Q0P4L7; -.
DR   DNASU; 549186; -.
DR   GeneID; 549186; -.
DR   KEGG; xtr:549186; -.
DR   CTD; 55686; -.
DR   Xenbase; XB-GENE-5735017; mreg.
DR   eggNOG; ENOG502S05X; Eukaryota.
DR   HOGENOM; CLU_105265_0_0_1; -.
DR   InParanoid; Q0P4L7; -.
DR   OMA; CRCLEEP; -.
DR   OrthoDB; 1250643at2759; -.
DR   TreeFam; TF334733; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR   GO; GO:0031300; C:intrinsic component of organelle membrane; ISS:UniProtKB.
DR   GO; GO:0031902; C:late endosome membrane; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042470; C:melanosome; IBA:GO_Central.
DR   GO; GO:0033162; C:melanosome membrane; ISS:UniProtKB.
DR   GO; GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.
DR   GO; GO:0030318; P:melanocyte differentiation; IBA:GO_Central.
DR   GO; GO:0032400; P:melanosome localization; ISS:UniProtKB.
DR   GO; GO:0032402; P:melanosome transport; IBA:GO_Central.
DR   GO; GO:0090382; P:phagosome maturation; ISS:UniProtKB.
DR   InterPro; IPR031638; Melanoregulin.
DR   PANTHER; PTHR34340; PTHR34340; 1.
DR   Pfam; PF15812; MREG; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasmic vesicle; Lipid-binding; Lipoprotein; Lysosome;
KW   Membrane; Reference proteome; Transport.
FT   CHAIN           1..196
FT                   /note="Melanoregulin"
FT                   /id="PRO_0000292178"
SQ   SEQUENCE   196 AA;  23232 MW;  9BB85A05BBF7FABB CRC64;
     MCLKDWLCAF CCLRLGCLEY PKNEKQPLVS GNNNQYKTYA VIDDDERNLW SSPHDLSHTE
     AVDDRMLQSW IQTRNQLEKD SEEWQKLNYE IYTLRQARRE VRARWRRILE DLGFQKEAET
     LLSVTKQSTI SNPKNMKRAM ELLVKLSDNT TIFPAGWDLP VRYLYIMDRL ICLDAVDDFL
     NIAQKKYPKT KMDISQ