ID   MRFL_BOVIN              Reviewed;         896 AA.
AC   F1N4M2; A6QNP2;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Myelin regulatory factor-like protein;
GN   Name=MYRFL;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MRF family. {ECO:0000305}.
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DR   EMBL; DAAA02013219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02013220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02013221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02013222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC148934; AAI48935.1; -; mRNA.
DR   RefSeq; NP_001095793.1; NM_001102323.1.
DR   AlphaFoldDB; F1N4M2; -.
DR   SMR; F1N4M2; -.
DR   STRING; 9913.ENSBTAP00000019581; -.
DR   PaxDb; F1N4M2; -.
DR   PRIDE; F1N4M2; -.
DR   Ensembl; ENSBTAT00000019581; ENSBTAP00000019581; ENSBTAG00000014829.
DR   GeneID; 781109; -.
DR   KEGG; bta:781109; -.
DR   CTD; 196446; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014829; -.
DR   VGNC; VGNC:31845; MYRFL.
DR   eggNOG; KOG3661; Eukaryota.
DR   GeneTree; ENSGT00530000063626; -.
DR   HOGENOM; CLU_004919_1_0_1; -.
DR   InParanoid; F1N4M2; -.
DR   OMA; CHNPGAS; -.
DR   OrthoDB; 311898at2759; -.
DR   TreeFam; TF312888; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000014829; Expressed in jejunum and 42 other tissues.
DR   ExpressionAtlas; F1N4M2; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0016540; P:protein autoprocessing; IBA:GO_Central.
DR   Gene3D; 2.60.40.1390; -; 1.
DR   InterPro; IPR025719; MYRF_C2.
DR   InterPro; IPR026932; MYRF_ICA.
DR   InterPro; IPR024061; NDT80_DNA-bd_dom.
DR   InterPro; IPR037141; NDT80_DNA-bd_dom_sf.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR030392; S74_ICA.
DR   Pfam; PF13888; MRF_C2; 1.
DR   Pfam; PF13887; MYRF_ICA; 1.
DR   Pfam; PF05224; NDT80_PhoG; 1.
DR   Pfam; PF13884; Peptidase_S74; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS51688; ICA; 1.
DR   PROSITE; PS51517; NDT80; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA-binding; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..896
FT                   /note="Myelin regulatory factor-like protein"
FT                   /id="PRO_0000420955"
FT   TRANSMEM        622..638
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          449..557
FT                   /note="Peptidase S74"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01025"
FT   DNA_BIND        111..403
FT                   /note="NDT80"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00850"
FT   REGION          648..672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          541..573
FT                   /evidence="ECO:0000255"
FT   CONFLICT        439
FT                   /note="M -> V (in Ref. 2; AAI48935)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   896 AA;  100085 MW;  E89E029D07AB0F02 CRC64;
     MDVVGENEAL QQFFEAQGAN GTLGNPTLDT SLLEEFLGND FDLGALQGQL PDTPPYSASD
     SCSPPQVKGA CCPTLTPAAR GTPAALLHSA NAPGILPAHQ SHSSSEMSNS GLPHRTFHNC
     YPDASHLMSP LDQSVSGGIG CSYHQQPLCH SPGVSLPPTK KRKCTQVLED SGDCHVWTHH
     SRPMTGRSHS IEVQDLDSER QNMMLADQPS PALKWQPYRS VPWHSLLNSQ YEKLPDVGYR
     VVTDKGFNFS PADEAFVCQK KNHFQITIHI QVWGSPKFVK TQMGLKPIEM FYLKPFGVKV
     EATNQIIAIE QSQADRSKKI FNPIKINLLA DQVTKVTLGR LHFSETTANN MRKKGKPNPD
     QRYFMLVVGL YAANQDQFYL LSAHISERII VRASNPGQFE NDIDALWQRG QVPESVVCHG
     RVGINTDAPD EALVVCGNMK VMGTIMHPSD SRAKQNVQEV DTNEQLRRIA QMRIVEYDYK
     PEFASAMGIN TAHQTGMIAQ EVREILPRAV REVGDVTCEN GETLENFLMV DKDQIFMENV
     GAVKQLCKLT NNLEERIEEL EIWNRKLARL KRLSSSKSSA SEASSISKFS RALSASSPKR
     TISKKNSKVS FSGKKQSCPN WVFQSLVITL IAVMAFCLKD QDRCTPSAPS SNLTSSQEPA
     LPSTASPSAP NTTLATTLPS FQVPEITFCE ILPCQQTYCC PIWGTRRGLS SPMQRQLEEQ
     EPHQGPWAGR STSFLAAEAQ TNVDWRSDWI DTTISSIQIM EIQQIIDRRY CSRSLQCGSG
     NYYYHIPVNK YTPTNVKFSL EINTTEPLIV FQCKFTLGNM CFRSKIEAKG MESQQEVSQE
     MTQGYQHIWS LPVAPLFDSG YHFRVAAPDL ADCSTDPYFA GKFFTDYFFY FYRHCV