MRFL_MOUSE
ID MRFL_MOUSE Reviewed; 904 AA.
AC Q3UN70; Q3UN89;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Myelin regulatory factor-like protein;
GN Name=Myrfl; Synonyms=Gm239;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Intestinal mucosa;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MRF family. {ECO:0000305}.
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DR EMBL; AK144411; BAE25877.1; -; mRNA.
DR EMBL; AK144383; BAE25858.1; -; mRNA.
DR EMBL; AC123720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC132304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC150915; AAI50916.1; -; mRNA.
DR EMBL; BC150923; AAI50924.1; -; mRNA.
DR CCDS; CCDS36066.1; -.
DR RefSeq; NP_001028505.1; NM_001033333.3.
DR AlphaFoldDB; Q3UN70; -.
DR SMR; Q3UN70; -.
DR iPTMnet; Q3UN70; -.
DR PhosphoSitePlus; Q3UN70; -.
DR MaxQB; Q3UN70; -.
DR PaxDb; Q3UN70; -.
DR PRIDE; Q3UN70; -.
DR ProteomicsDB; 291400; -.
DR Antibodypedia; 62193; 5 antibodies from 5 providers.
DR Ensembl; ENSMUST00000048229; ENSMUSP00000037477; ENSMUSG00000034057.
DR GeneID; 237558; -.
DR KEGG; mmu:237558; -.
DR UCSC; uc007hci.1; mouse.
DR CTD; 196446; -.
DR MGI; MGI:2685085; Myrfl.
DR VEuPathDB; HostDB:ENSMUSG00000034057; -.
DR eggNOG; KOG3661; Eukaryota.
DR GeneTree; ENSGT00530000063626; -.
DR HOGENOM; CLU_004919_1_0_1; -.
DR InParanoid; Q3UN70; -.
DR OMA; CHNPGAS; -.
DR OrthoDB; 311898at2759; -.
DR PhylomeDB; Q3UN70; -.
DR TreeFam; TF312888; -.
DR BioGRID-ORCS; 237558; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Myrfl; mouse.
DR PRO; PR:Q3UN70; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q3UN70; protein.
DR Bgee; ENSMUSG00000034057; Expressed in paneth cell and 35 other tissues.
DR Genevisible; Q3UN70; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0016540; P:protein autoprocessing; IBA:GO_Central.
DR Gene3D; 2.60.40.1390; -; 1.
DR InterPro; IPR025719; MYRF_C2.
DR InterPro; IPR026932; MYRF_ICA.
DR InterPro; IPR024061; NDT80_DNA-bd_dom.
DR InterPro; IPR037141; NDT80_DNA-bd_dom_sf.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR030392; S74_ICA.
DR Pfam; PF13888; MRF_C2; 1.
DR Pfam; PF13887; MYRF_ICA; 1.
DR Pfam; PF05224; NDT80_PhoG; 1.
DR Pfam; PF13884; Peptidase_S74; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS51688; ICA; 1.
DR PROSITE; PS51517; NDT80; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; DNA-binding; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..904
FT /note="Myelin regulatory factor-like protein"
FT /id="PRO_0000420956"
FT TRANSMEM 624..644
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 446..554
FT /note="Peptidase S74"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01025"
FT DNA_BIND 108..400
FT /note="NDT80"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00850"
FT REGION 46..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 538..575
FT /evidence="ECO:0000255"
FT COMPBIAS 95..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 682
FT /note="T -> N (in Ref. 1; BAE25858)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 904 AA; 101689 MW; D9E66E53A34B3221 CRC64;
MDVLGENEAL QQFFEAQGAS GTLENPALDT SLLEEFLGND FDLGALQRQL PDTPPYSASD
PRSPPQVKGA CCRTPRPPAG RIPAAFLHST TAPGPLPEHP SQSMAGQTHS SFQNGYPESS
HPATCRHQTG PSRLGTSCSF HQQPLCHVPG SSLPPTKKRK HSQIQEDSWD CSSWAHYFRP
MTTRSQSIEV QDHDREGRNG MPVDQCSPAL KWQPYQSVPW HSLLNSRYEK LPEVGYQVVT
DKGFTFSPVD EAFVCQKKNH FQITVHIQVW GSPKFVKTQV GLKPIEKFYL KAFGIKVEAT
NQVIAIEQSQ ADRSKKTFDP VKIDLLTDQV TKVTLGRLHF SETTANNMRK KGKPNPDQRY
FMLVVGLYAA NQDQFYLLAA HISERIIVRA SNPGQFENDS DALWQRGQVP ESIVCHGRVG
INTDTPDEAL VVCGNMKVMG TVMHPSDSRV KENIQEVDTN EQLRRIAQMR IVQYDYKPEF
ASAMGINTAH QTGMIAQEVQ EILPRAVREV GDVTGGNGET LENFLMVDKD QIFMENVGAV
KQLCKLTNNL EERIEELEIW NKKLARLKRL SSSWKSSISE ASSISKLSRA VSASSARRTG
SKKPTKVSFS GRKQSCPNWV FQTLVVVLIA VMAFCALTIV ALYILSLKDQ DRRSPNLPLS
NMTSSPEPAL SSTAPTSAPH TTPETTQTSL QVPEITFCEI LPCQETYCCP VWGPRILFSS
PAQRQLEAER EIHQRQWAED KSKSFLTSSA LISPDWESDW IDTTIASIQI VEIQQMIDRR
YCSRMLHCGP GHYNYNIPVN KNTPTNVKFS LEINTTEPLI VFQCKYTLGN ICFRSQRERT
QSDGEDAQMT QGYQHIWRLP VARFSDSAYH FRVAAPDLAD CSTDPFFAGI FFTDYFFYFY
RRCN
