MRGA2_MOUSE
ID MRGA2_MOUSE Reviewed; 305 AA.
AC Q91WW4; Q6P3D5;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=Mas-related G-protein coupled receptor member A2;
GN Name=Mrgpra2; Synonyms=Mrga2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J; TISSUE=Spinal ganglion;
RX PubMed=11551509; DOI=10.1016/s0092-8674(01)00483-4;
RA Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.;
RT "A diverse family of GPCRs expressed in specific subsets of nociceptive
RT sensory neurons.";
RL Cell 106:619-632(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor. May be a receptor for RFamide-family
CC neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May
CC regulate nociceptor function and/or development, including the
CC sensation or modulation of pain (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in a subset of sensory neurons that
CC includes nociceptors. Expressed in the subclass of non-peptidergic
CC sensory neurons that are IB4(+) and VR1(-).
CC {ECO:0000269|PubMed:11551509}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH64040.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY042192; AAK91788.1; -; mRNA.
DR EMBL; BC064040; AAH64040.1; ALT_INIT; mRNA.
DR RefSeq; NP_001166059.1; NM_001172588.1.
DR RefSeq; NP_694741.2; NM_153101.3.
DR AlphaFoldDB; Q91WW4; -.
DR SMR; Q91WW4; -.
DR STRING; 10090.ENSMUSP00000113310; -.
DR PaxDb; Q91WW4; -.
DR PRIDE; Q91WW4; -.
DR DNASU; 235712; -.
DR GeneID; 235712; -.
DR GeneID; 668727; -.
DR KEGG; mmu:235712; -.
DR KEGG; mmu:668727; -.
DR CTD; 235712; -.
DR CTD; 668727; -.
DR MGI; MGI:3033098; Mrgpra2.
DR eggNOG; ENOG502RTWA; Eukaryota.
DR InParanoid; Q91WW4; -.
DR OrthoDB; 1123658at2759; -.
DR PhylomeDB; Q91WW4; -.
DR TreeFam; TF336336; -.
DR BioGRID-ORCS; 235712; 2 hits in 38 CRISPR screens.
DR BioGRID-ORCS; 668727; 5 hits in 39 CRISPR screens.
DR PRO; PR:Q91WW4; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q91WW4; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026233; MRGPCRA.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF33; PTHR11334:SF33; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02109; MRGPCRA.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..305
FT /note="Mas-related G-protein coupled receptor member A2"
FT /id="PRO_0000069748"
FT TOPO_DOM 1..17
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..78
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..167
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..207
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..244
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 91
FT /note="M -> I (in Ref. 2; AAH64040)"
FT /evidence="ECO:0000305"
FT CONFLICT 243
FT /note="F -> L (in Ref. 2; AAH64040)"
FT /evidence="ECO:0000305"
FT CONFLICT 271
FT /note="Q -> R (in Ref. 2; AAH64040)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 305 AA; 34427 MW; 2093474029CCF946 CRC64;
MDETLPGSIN IRILIPKLMI IIFGLVGLMG NAIVFWLLGF HLRRNAFSVY ILNLALADFL
FLLSSIIAST LFLLKVSYLS IIFHLCFNTI MMVVYITGIS MLSAISTECC LSVLCPTWYR
CHRPVHTSTV MCAVIWVLSL LICILNSYFC AVLHTRYDND NECLATNIFT ASYMIFLLVV
LCLSSLALLA RLFCGAGQMK LTRFHVTILL TLLVFLLCGL PFVIYCILLF KIKDDFHVLD
VNFYLALEVL TAINSCANPI IYFFVGSFRH QLKHQTLKMV LQSALQDTPE TAENMVEMSS
NKAEP
