MRGA5_MOUSE
ID MRGA5_MOUSE Reviewed; 304 AA.
AC Q91ZC7;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 2.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Mas-related G-protein coupled receptor member A5;
GN Name=Mrgpra5; Synonyms=Mrga5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=129/SvJ;
RX PubMed=11551509; DOI=10.1016/s0092-8674(01)00483-4;
RA Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.;
RT "A diverse family of GPCRs expressed in specific subsets of nociceptive
RT sensory neurons.";
RL Cell 106:619-632(2001).
CC -!- FUNCTION: Orphan receptor. May be a receptor for RFamide-family
CC neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May
CC regulate nociceptor function and/or development, including the
CC sensation or modulation of pain (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in a subset of sensory neurons that
CC includes nociceptors. Expressed in the subclass of non-peptidergic
CC sensory neurons that are IB4(+) and VR1(-).
CC {ECO:0000269|PubMed:11551509}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK91791.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY042195; AAK91791.1; ALT_FRAME; Genomic_DNA.
DR RefSeq; NP_997417.1; NM_207534.1.
DR AlphaFoldDB; Q91ZC7; -.
DR SMR; Q91ZC7; -.
DR PRIDE; Q91ZC7; -.
DR DNASU; 404235; -.
DR GeneID; 404235; -.
DR KEGG; mmu:404235; -.
DR CTD; 404235; -.
DR MGI; MGI:3033102; Mrgpra5.
DR InParanoid; Q91ZC7; -.
DR PhylomeDB; Q91ZC7; -.
DR PRO; PR:Q91ZC7; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q91ZC7; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISO:MGI.
DR GO; GO:0042923; F:neuropeptide binding; ISO:MGI.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0045576; P:mast cell activation; ISO:MGI.
DR GO; GO:0043303; P:mast cell degranulation; ISO:MGI.
DR GO; GO:0032467; P:positive regulation of cytokinesis; ISO:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026233; MRGPCRA.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF33; PTHR11334:SF33; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02109; MRGPCRA.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..304
FT /note="Mas-related G-protein coupled receptor member A5"
FT /id="PRO_0000069751"
FT TOPO_DOM 1..18
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 19..39
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 40..45
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..80
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..172
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..208
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..244
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..304
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 304 AA; 35095 MW; EDB49BC5BBFC3C28 CRC64;
MDKPLWKYGH LDSDPKLMII IFRLVGMTGN AIVFWLLGFS LHRNAFSVYI LNLALADFVF
LLCHIIDSML LLLTVFYPNN IFSGYFYTIM TVPYIAGLSM LSAISTELCL SVLCPIWYRC
HHPEHTSTVM CAAIWVLPLL VCILNRYFCS FLDINYNNDK QCLASNFFTR AYLMFLFVVL
CLSSMALLAR LFCGTGQMKL TRLYVTIMLT VLGFLLCGLP FVIYYFLLFN IKDGFCLFDF
RFYMSTHVLT AINNCANPII YFFEGSFRHQ LKHQTLKMVL QSVLQDTPEI AENMVEMSRN
IPKP
