MRGA6_MOUSE
ID MRGA6_MOUSE Reviewed; 301 AA.
AC Q91ZC6; A3KMK5; E9QN26;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-FEB-2014, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Mas-related G-protein coupled receptor member A6;
GN Name=Mrgpra6; Synonyms=Mrga6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=129/SvJ;
RX PubMed=11551509; DOI=10.1016/s0092-8674(01)00483-4;
RA Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.;
RT "A diverse family of GPCRs expressed in specific subsets of nociceptive
RT sensory neurons.";
RL Cell 106:619-632(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor. May be a receptor for RFamide-family
CC neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May
CC regulate nociceptor function and/or development, including the
CC sensation or modulation of pain (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in a subset of sensory neurons that
CC includes nociceptors. Expressed in the subclass of non-peptidergic
CC sensory neurons that are IB4(+) and VR1(-).
CC {ECO:0000269|PubMed:11551509}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY042196; AAK91792.1; -; Genomic_DNA.
DR EMBL; AC115898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC132198; AAI32199.1; -; mRNA.
DR EMBL; BC132204; AAI32205.1; -; mRNA.
DR RefSeq; NP_001295466.1; NM_001308537.1.
DR AlphaFoldDB; Q91ZC6; -.
DR SMR; Q91ZC6; -.
DR PaxDb; Q91ZC6; -.
DR PRIDE; Q91ZC6; -.
DR Ensembl; ENSMUST00000073793; ENSMUSP00000073463; ENSMUSG00000052303.
DR GeneID; 381886; -.
DR KEGG; mmu:381886; -.
DR CTD; 381886; -.
DR MGI; MGI:3033107; Mrgpra6.
DR VEuPathDB; HostDB:ENSMUSG00000052303; -.
DR eggNOG; ENOG502RTWA; Eukaryota.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q91ZC6; -.
DR OMA; WFLAIRI; -.
DR PhylomeDB; Q91ZC6; -.
DR TreeFam; TF336336; -.
DR BioGRID-ORCS; 381886; 0 hits in 50 CRISPR screens.
DR PRO; PR:Q91ZC6; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q91ZC6; protein.
DR Bgee; ENSMUSG00000052303; Expressed in spermatid.
DR ExpressionAtlas; Q91ZC6; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISO:MGI.
DR GO; GO:0042923; F:neuropeptide binding; ISO:MGI.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0045576; P:mast cell activation; ISO:MGI.
DR GO; GO:0043303; P:mast cell degranulation; ISO:MGI.
DR GO; GO:0032467; P:positive regulation of cytokinesis; ISO:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026233; MRGPCRA.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF33; PTHR11334:SF33; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02109; MRGPCRA.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..301
FT /note="Mas-related G-protein coupled receptor member A6"
FT /id="PRO_0000069752"
FT TOPO_DOM 1..15
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..42
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..77
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..163
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..240
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..301
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 96
FT /note="N -> S (in Ref. 1; AAK91792 and 3; AAI32199/
FT AAI32205)"
FT /evidence="ECO:0000305"
FT CONFLICT 119
FT /note="R -> S (in Ref. 1; AAK91792 and 3; AAI32199/
FT AAI32205)"
FT /evidence="ECO:0000305"
FT CONFLICT 233
FT /note="S -> T (in Ref. 1; AAK91792 and 3; AAI32199/
FT AAI32205)"
FT /evidence="ECO:0000305"
FT CONFLICT 242
FT /note="T -> A (in Ref. 1; AAK91792 and 3; AAI32199/
FT AAI32205)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 301 AA; 34538 MW; BCA7A50CF5A78F91 CRC64;
MHRSISIRIL ITNLMIVILG LVGLTGNAIV FWLLLFRLRR NAFSIYILNL ALADFLFLLC
HIIASTEHIL TFSSPNSIFI NCLYTFRVLL YIAGLNMLSA ISIERCLSVM CPIWYRCHRP
EHTSTVMCAM IWVLSLLLCI LYRYFCGFLD TKYEDDYGCL AMNFLTTAYL MFLFVVLCVS
SLALLARLFC GAGRMKLTRL YVTITLTLLV FLLCGLPCGF YWFLLSKIKN VFSVFEFSLY
LTSVVLTAIN SCANPIIYFF VGSFRHRLKH QTLKMVLQSA LQDTPETPEN MVEMSRNKAE
L
