MRGA7_MOUSE
ID MRGA7_MOUSE Reviewed; 305 AA.
AC Q91ZC5;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Mas-related G-protein coupled receptor member A7;
GN Name=Mrgpra7; Synonyms=Mrga7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=129/SvJ;
RX PubMed=11551509; DOI=10.1016/s0092-8674(01)00483-4;
RA Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.;
RT "A diverse family of GPCRs expressed in specific subsets of nociceptive
RT sensory neurons.";
RL Cell 106:619-632(2001).
CC -!- FUNCTION: Orphan receptor. May be a receptor for RFamide-family
CC neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May
CC regulate nociceptor function and/or development, including the
CC sensation or modulation of pain (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in a subset of sensory neurons that
CC includes nociceptors. Expressed in the subclass of non-peptidergic
CC sensory neurons that are IB4(+) and VR1(-).
CC {ECO:0000269|PubMed:11551509}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY042197; AAK91793.1; -; Genomic_DNA.
DR RefSeq; NP_997418.1; NM_207535.1.
DR AlphaFoldDB; Q91ZC5; -.
DR SMR; Q91ZC5; -.
DR iPTMnet; Q91ZC5; -.
DR PhosphoSitePlus; Q91ZC5; -.
DR PRIDE; Q91ZC5; -.
DR DNASU; 404236; -.
DR GeneID; 404236; -.
DR KEGG; mmu:404236; -.
DR CTD; 404236; -.
DR MGI; MGI:3033109; Mrgpra7.
DR InParanoid; Q91ZC5; -.
DR PhylomeDB; Q91ZC5; -.
DR PRO; PR:Q91ZC5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q91ZC5; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISO:MGI.
DR GO; GO:0042923; F:neuropeptide binding; ISO:MGI.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0045576; P:mast cell activation; ISO:MGI.
DR GO; GO:0043303; P:mast cell degranulation; ISO:MGI.
DR GO; GO:0032467; P:positive regulation of cytokinesis; ISO:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026233; MRGPCRA.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF33; PTHR11334:SF33; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02109; MRGPCRA.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..305
FT /note="Mas-related G-protein coupled receptor member A7"
FT /id="PRO_0000069753"
FT TOPO_DOM 1..17
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..129
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..167
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..211
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..244
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 305 AA; 35034 MW; 2544FDB3B9E26D39 CRC64;
MDETSPRSID IESLIPNLMI IIFGLVGLTG NAIVLWLLGF CLHRNAFLVY ILNLALADFL
FLLCHFINSA MFLLKVPIPN GIFVYCFYTI KMVLYITGLS MLSAISTERC LSVLCPIWYH
CRRPEHTSTV MCAVIWIFSV LICILKEYFC DFFGTKLGNY YVCQASNFFM GAYLMFLFVV
LCLSTLALLA RLFCGAEKMK FTRLFVTIML TILVFLLCGL PWGFFWFLLI WIKGGFSVLD
YRLYLASIVL TVVNSCANPI IYFFVGSFRH RLKHQTLKMV LQSALQDTPE THENMVEMSR
IKAEQ
