MRGB3_MOUSE
ID MRGB3_MOUSE Reviewed; 312 AA.
AC Q91ZC1; Q3B813; Q3B814;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Mas-related G-protein coupled receptor member B3;
GN Name=Mrgprb3; Synonyms=Mrgb3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=11551509; DOI=10.1016/s0092-8674(01)00483-4;
RA Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.;
RT "A diverse family of GPCRs expressed in specific subsets of nociceptive
RT sensory neurons.";
RL Cell 106:619-632(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-312.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor. Probably involved in the function of
CC nociceptive neurons. May regulate nociceptor function and/or
CC development, including the sensation or modulation of pain (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY042201; AAK91797.1; -; Genomic_DNA.
DR EMBL; BC107192; AAI07193.1; -; mRNA.
DR EMBL; BC107193; AAI07194.1; -; mRNA.
DR EMBL; BC114400; AAI14401.1; -; mRNA.
DR EMBL; BC114428; AAI14429.1; -; mRNA.
DR CCDS; CCDS21304.1; -.
DR RefSeq; NP_997420.1; NM_207537.1.
DR AlphaFoldDB; Q91ZC1; -.
DR SMR; Q91ZC1; -.
DR STRING; 10090.ENSMUSP00000091945; -.
DR iPTMnet; Q91ZC1; -.
DR PhosphoSitePlus; Q91ZC1; -.
DR PaxDb; Q91ZC1; -.
DR PRIDE; Q91ZC1; -.
DR DNASU; 404238; -.
DR Ensembl; ENSMUST00000094383; ENSMUSP00000091945; ENSMUSG00000070546.
DR GeneID; 404238; -.
DR KEGG; mmu:404238; -.
DR UCSC; uc009hau.1; mouse.
DR CTD; 404238; -.
DR MGI; MGI:3033117; Mrgprb3.
DR VEuPathDB; HostDB:ENSMUSG00000070546; -.
DR eggNOG; ENOG502RTWA; Eukaryota.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q91ZC1; -.
DR OMA; SIRHGKF; -.
DR OrthoDB; 1123658at2759; -.
DR PhylomeDB; Q91ZC1; -.
DR TreeFam; TF336336; -.
DR BioGRID-ORCS; 404238; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q91ZC1; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q91ZC1; protein.
DR Bgee; ENSMUSG00000070546; Expressed in zone of skin and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISO:MGI.
DR GO; GO:0042923; F:neuropeptide binding; ISO:MGI.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0045576; P:mast cell activation; ISO:MGI.
DR GO; GO:0043303; P:mast cell degranulation; ISO:MGI.
DR GO; GO:0032467; P:positive regulation of cytokinesis; ISO:MGI.
DR InterPro; IPR019430; 7TM_GPCR_serpentine_rcpt_Srx.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR Pfam; PF10328; 7TM_GPCR_Srx; 1.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Membrane; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Mas-related G-protein coupled receptor member B3"
FT /id="PRO_0000305298"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..180
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..220
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..259
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 301
FT /note="G -> D (in Ref. 2; AAI07193)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 35510 MW; D71FF8F6008B2129 CRC64;
MALRTSLITT TAPDKTSLPI SICIIKFQVM NLLSITISPV GMVLNIIVLW FLGFQICRNA
FSAYILNLAV ADFLFLCSHS IFSFLIVCKL HYFLFYIRQL LDTVTMFAYV FGLSITTIIS
IECCLSIMWP IWYHCQRPRH TSAVICVLLW ALSLLFPALQ MEKCSVLFNT FEYSWCGIIN
IISGAWLVVL FVVLCGFSLI LLLRISCGSQ QIPVTRLNVT IALRVLLLLI FGIPFGIFWI
VDKWNEENFF VRACGFSHHI LYVYCINICV NATIYFLVGS IRHGKFQKMT LKLILQRAIQ
GTPEEEGGER GP
