MRGB4_MOUSE
ID MRGB4_MOUSE Reviewed; 321 AA.
AC Q91ZC0; Q3B811;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Mas-related G-protein coupled receptor member B4;
GN Name=Mrgprb4; Synonyms=Mrgb4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=11551509; DOI=10.1016/s0092-8674(01)00483-4;
RA Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.;
RT "A diverse family of GPCRs expressed in specific subsets of nociceptive
RT sensory neurons.";
RL Cell 106:619-632(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-321.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor. Probably involved in the function of
CC nociceptive neurons. May regulate nociceptor function and/or
CC development, including the sensation or modulation of pain (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY042202; AAK91798.1; -; Genomic_DNA.
DR EMBL; BC107202; AAI07203.1; -; mRNA.
DR EMBL; BC107203; AAI07204.1; -; mRNA.
DR CCDS; CCDS21301.1; -.
DR RefSeq; NP_991364.1; NM_205795.1.
DR AlphaFoldDB; Q91ZC0; -.
DR SMR; Q91ZC0; -.
DR STRING; 10090.ENSMUSP00000091952; -.
DR GlyGen; Q91ZC0; 3 sites.
DR PaxDb; Q91ZC0; -.
DR PRIDE; Q91ZC0; -.
DR DNASU; 233230; -.
DR Ensembl; ENSMUST00000094388; ENSMUSP00000091952; ENSMUSG00000070550.
DR GeneID; 233230; -.
DR KEGG; mmu:233230; -.
DR UCSC; uc009han.1; mouse.
DR CTD; 233230; -.
DR MGI; MGI:3033119; Mrgprb4.
DR VEuPathDB; HostDB:ENSMUSG00000070550; -.
DR eggNOG; ENOG502RTWA; Eukaryota.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q91ZC0; -.
DR OMA; GCGFLFS; -.
DR OrthoDB; 1123658at2759; -.
DR PhylomeDB; Q91ZC0; -.
DR TreeFam; TF336336; -.
DR BioGRID-ORCS; 233230; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q91ZC0; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q91ZC0; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISO:MGI.
DR GO; GO:0042923; F:neuropeptide binding; ISO:MGI.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0045576; P:mast cell activation; ISO:MGI.
DR GO; GO:0043303; P:mast cell degranulation; ISO:MGI.
DR GO; GO:0032467; P:positive regulation of cytokinesis; ISO:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..321
FT /note="Mas-related G-protein coupled receptor member B4"
FT /id="PRO_0000305299"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..62
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..172
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..215
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 237..257
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 299..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 321 AA; 36338 MW; CBDF185B470DB8B4 CRC64;
MGTTTLAWNI NNTAENGSYT EMFSCITKFN TLNFLTVIIA VVGLAGNGIV LWLLAFHLHR
NAFSVYVLNL AGADFLYLFT QVVHSLECVL QLDNNSFYIL LIVTMFAYLA GLCMIAAISA
ERCLSVMWPI WYHCQRPRHT SAIMCALVWV SSLLLSLVVG LGCGFLFSYY DYYFCITLNF
ITAAFLIVLS VVLSVSSLAL LVKIVWGSHR IPVTRFFVTI ALTVVVFIYF GMPFGICWFL
LSRIMEFDSI FFNNVYEIIE FLSCVNSCAN PIIYFLVGSI RQHRLRWQSL KLLLQRAMQD
TPEEESGERG PSQRSGELET V
