ID   MRGB4_RAT               Reviewed;         323 AA.
AC   Q7TN45;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Mas-related G-protein coupled receptor member B4;
GN   Name=Mrgprb4; Synonyms=Mrgb4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=12909716; DOI=10.1073/pnas.1732949100;
RA   Zylka M.J., Dong X., Southwell A.L., Anderson D.J.;
RT   "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-
RT   coupled receptor family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
CC   -!- FUNCTION: Orphan receptor. Probably involved in the function of
CC       nociceptive neurons. May regulate nociceptor function and/or
CC       development, including the sensation or modulation of pain (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed strongly in newborn dorsal root ganglia,
CC       adult dorsal root ganglia and trigeminal ganlia.
CC       {ECO:0000269|PubMed:12909716}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF518242; AAQ08314.1; -; Genomic_DNA.
DR   RefSeq; NP_001002287.1; NM_001002287.1.
DR   AlphaFoldDB; Q7TN45; -.
DR   SMR; Q7TN45; -.
DR   STRING; 10116.ENSRNOP00000043206; -.
DR   GlyGen; Q7TN45; 1 site.
DR   PaxDb; Q7TN45; -.
DR   PRIDE; Q7TN45; -.
DR   GeneID; 404658; -.
DR   KEGG; rno:404658; -.
DR   UCSC; RGD:738043; rat.
DR   CTD; 233230; -.
DR   RGD; 738043; Mrgprb4.
DR   VEuPathDB; HostDB:ENSRNOG00000033021; -.
DR   eggNOG; ENOG502RTWA; Eukaryota.
DR   HOGENOM; CLU_009579_4_1_1; -.
DR   InParanoid; Q7TN45; -.
DR   OMA; GCGFLFS; -.
DR   OrthoDB; 1123658at2759; -.
DR   PhylomeDB; Q7TN45; -.
DR   TreeFam; TF336336; -.
DR   PRO; PR:Q7TN45; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR026234; MRGPCRFAMILY.
DR   PANTHER; PTHR11334; PTHR11334; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR02108; MRGPCRFAMILY.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..323
FT                   /note="Mas-related G-protein coupled receptor member B4"
FT                   /id="PRO_0000305300"
FT   TOPO_DOM        1..34
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        56..63
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        85..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..147
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        169..180
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        202..224
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        246..255
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        277..323
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          298..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        299..314
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        11
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   323 AA;  36787 MW;  AB034809B0024BA6 CRC64;
     MSPTTQAWSI NNTVVKENYY TEILSCITTF NTLNFLIVII SVVGMAGNAT VLWLLGFHMH
     RNAFSVYVLN LAGADFLYLC AQTVYSLECV LQFDNSYFYF LLTILMFNYL AGFCMIAAIS
     TERCLSVTWP IWYHCQRPRH TSATVCALFW AFSLLLSLLL GQGCGFLFSK FDYSFCRYCN
     FIATAFLIVI FMVLFVSSLA LLAKIICGSH RIPVTRFYVT IALTVLVFIF FGLPIGICVF
     LLPWIHMMLS SFFYEMVTLL SCVNSCANPI IYFFVGSIRH HRLQRQTLKL LLQRAMQDTP
     EEEGGERGPS QKSEDLEVVR CSS