MRGB5_MOUSE
ID MRGB5_MOUSE Reviewed; 322 AA.
AC Q91ZB9;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Mas-related G-protein coupled receptor member B5;
GN Name=Mrgprb5; Synonyms=Mrgb5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=11551509; DOI=10.1016/s0092-8674(01)00483-4;
RA Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.;
RT "A diverse family of GPCRs expressed in specific subsets of nociceptive
RT sensory neurons.";
RL Cell 106:619-632(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor. Probably involved in the function of
CC nociceptive neurons. May regulate nociceptor function and/or
CC development, including the sensation or modulation of pain (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY042203; AAK91799.1; -; Genomic_DNA.
DR EMBL; BC120849; AAI20850.1; -; mRNA.
DR EMBL; BC132003; AAI32004.1; -; mRNA.
DR CCDS; CCDS21300.1; -.
DR RefSeq; NP_997421.1; NM_207538.1.
DR AlphaFoldDB; Q91ZB9; -.
DR SMR; Q91ZB9; -.
DR STRING; 10090.ENSMUSP00000091953; -.
DR GlyGen; Q91ZB9; 3 sites.
DR PaxDb; Q91ZB9; -.
DR PRIDE; Q91ZB9; -.
DR DNASU; 404239; -.
DR Ensembl; ENSMUST00000094389; ENSMUSP00000091953; ENSMUSG00000070551.
DR GeneID; 404239; -.
DR KEGG; mmu:404239; -.
DR UCSC; uc009ham.1; mouse.
DR CTD; 404239; -.
DR MGI; MGI:3033121; Mrgprb5.
DR VEuPathDB; HostDB:ENSMUSG00000070551; -.
DR eggNOG; ENOG502RTWA; Eukaryota.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q91ZB9; -.
DR OMA; PAWNINN; -.
DR OrthoDB; 1148052at2759; -.
DR PhylomeDB; Q91ZB9; -.
DR TreeFam; TF336336; -.
DR BioGRID-ORCS; 404239; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q91ZB9; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q91ZB9; protein.
DR ExpressionAtlas; Q91ZB9; differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISO:MGI.
DR GO; GO:0042923; F:neuropeptide binding; ISO:MGI.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0045576; P:mast cell activation; ISO:MGI.
DR GO; GO:0043303; P:mast cell degranulation; ISO:MGI.
DR GO; GO:0032467; P:positive regulation of cytokinesis; ISO:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..322
FT /note="Mas-related G-protein coupled receptor member B5"
FT /id="PRO_0000305301"
FT TOPO_DOM 1..34
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..172
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..216
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..260
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..322
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 302..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 322 AA; 36285 MW; 24E83CBBE0289B8D CRC64;
MGLTTPAWNI NNTVVNGSNN TEHFSCVSKF NTLNFLTVII AMFGLAGNAI VLWLLAFHLP
RNAFSVYVCN LACADFLQLC TQILGSLECF LQLNRRHTFF LTVVFMFAYL AGLCMIAAIS
VERSLSVMWP IWYHCQRPRH TSSIMCALLW AFCLLLNFLL GEGCGLLFSD PKYYFCITCA
LITTALIILL TVVPSVSSLA LLVKMICGSH RIPVTRFYVT IALTLVVFIF LGLPFGIYSS
FLIMFKEFQS IFSYHVLEVT IFLSCVNSCA NPIIYFLVGS IRQHRLQWQS LKLLLQRAMQ
DTPEEDSGER VPSQRSGELE SV
