ID   MRGB5_RAT               Reviewed;         353 AA.
AC   Q7TN44;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Mas-related G-protein coupled receptor member B5;
GN   Name=Mrgprb5; Synonyms=Mrgb5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=12909716; DOI=10.1073/pnas.1732949100;
RA   Zylka M.J., Dong X., Southwell A.L., Anderson D.J.;
RT   "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-
RT   coupled receptor family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
CC   -!- FUNCTION: Orphan receptor. Probably involved in the function of
CC       nociceptive neurons. May regulate nociceptor function and/or
CC       development, including the sensation or modulation of pain (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed strongly in newborn dorsal root ganglia,
CC       adult dorsal root ganglia and trigeminal ganlia.
CC       {ECO:0000269|PubMed:12909716}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF518243; AAQ08315.1; -; Genomic_DNA.
DR   RefSeq; NP_001002284.1; NM_001002284.1.
DR   AlphaFoldDB; Q7TN44; -.
DR   SMR; Q7TN44; -.
DR   STRING; 10116.ENSRNOP00000031272; -.
DR   GlyGen; Q7TN44; 2 sites.
DR   PaxDb; Q7TN44; -.
DR   GeneID; 404644; -.
DR   KEGG; rno:404644; -.
DR   UCSC; RGD:738052; rat.
DR   CTD; 404239; -.
DR   RGD; 738052; Mrgprb5.
DR   eggNOG; ENOG502RTWA; Eukaryota.
DR   InParanoid; Q7TN44; -.
DR   OrthoDB; 1123658at2759; -.
DR   PhylomeDB; Q7TN44; -.
DR   PRO; PR:Q7TN44; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR026234; MRGPCRFAMILY.
DR   PANTHER; PTHR11334; PTHR11334; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR02108; MRGPCRFAMILY.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..353
FT                   /note="Mas-related G-protein coupled receptor member B5"
FT                   /id="PRO_0000305302"
FT   TOPO_DOM        1..67
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..90
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        91..96
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..131
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        153..180
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        202..213
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..253
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        275..289
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        311..353
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          333..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        26
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        44
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   353 AA;  40125 MW;  CE3685C2D3A6A9E0 CRC64;
     MPDSPTESYG PDREYHVFIS LFLCRNTSGK FLSVGPATPG WSINNTVVKE NYYTEKLSCI
     ITFNTLNFLT ATISVVGTAG NATVLRLLGF HMHRYAFSVY VFNLAGADFL YLCTQTVYSL
     ECVLQFDNSY FYFLLTILMF AYLAALCMIP AISTERCLSV TWPIWYHCQR PRHTSATVCA
     LFWAFSLLLR LLLGQGCGFL FGKYDYYFCR YCSFITTAFL IVLFVVPFVS SLAMLTKIIC
     GSHRIPVTRF YVTIAVTVLV FTFFGLPVGI ISLLLPRIVV FRGVFYIYKI VTFLYSVNCC
     ANPIIYFLIG SIRHHRLQRQ SLKLLLQRAM QDTPEEEGGV KGPSQKSNEL EIV