MRGB8_MOUSE
ID MRGB8_MOUSE Reviewed; 330 AA.
AC Q7TN51; B2RR10;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Mas-related G-protein coupled receptor member B8;
GN Name=Mrgprb8; Synonyms=Mrgb8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=12909716; DOI=10.1073/pnas.1732949100;
RA Zylka M.J., Dong X., Southwell A.L., Anderson D.J.;
RT "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-
RT coupled receptor family.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor. Probably involved in the function of
CC nociceptive neurons. May regulate nociceptor function and/or
CC development, including the sensation or modulation of pain (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY266419; AAP20071.1; -; Genomic_DNA.
DR EMBL; BC138164; AAI38165.1; -; mRNA.
DR EMBL; BC138165; AAI38166.1; -; mRNA.
DR CCDS; CCDS21302.1; -.
DR RefSeq; NP_997422.1; NM_207539.2.
DR AlphaFoldDB; Q7TN51; -.
DR SMR; Q7TN51; -.
DR STRING; 10090.ENSMUSP00000052230; -.
DR GlyGen; Q7TN51; 1 site.
DR iPTMnet; Q7TN51; -.
DR PhosphoSitePlus; Q7TN51; -.
DR PaxDb; Q7TN51; -.
DR PRIDE; Q7TN51; -.
DR DNASU; 404240; -.
DR Ensembl; ENSMUST00000056676; ENSMUSP00000052230; ENSMUSG00000050870.
DR GeneID; 404240; -.
DR KEGG; mmu:404240; -.
DR UCSC; uc009hao.2; mouse.
DR CTD; 404240; -.
DR MGI; MGI:3033134; Mrgprb8.
DR VEuPathDB; HostDB:ENSMUSG00000050870; -.
DR eggNOG; ENOG502RTWA; Eukaryota.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q7TN51; -.
DR OMA; CANPIIC; -.
DR OrthoDB; 1123658at2759; -.
DR PhylomeDB; Q7TN51; -.
DR TreeFam; TF336336; -.
DR BioGRID-ORCS; 404240; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q7TN51; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q7TN51; protein.
DR Bgee; ENSMUSG00000050870; Expressed in testis and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISO:MGI.
DR GO; GO:0042923; F:neuropeptide binding; ISO:MGI.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0045576; P:mast cell activation; ISO:MGI.
DR GO; GO:0043303; P:mast cell degranulation; ISO:MGI.
DR GO; GO:0032467; P:positive regulation of cytokinesis; ISO:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR028328; MRGPCRB8.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF8; PTHR11334:SF8; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..330
FT /note="Mas-related G-protein coupled receptor member B8"
FT /id="PRO_0000305303"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..62
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..177
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..260
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..330
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 302..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..330
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 330 AA; 37892 MW; 7364621E87650729 CRC64;
MDSSFPDWNI EFREQNESYF MESSSCDMSL AMSLLSIIIA IIGLTGNVIV LQLLGFHMHR
NAFSVYIFNL SGANFLFLCT HIVFSLENLI RQFHYIDIHM ALFSVNVTIL AYLAGVSMIT
AISVEYWLSV LWPTWYHAQR PKHTSTVICT LLWVFSLLLT LWNWIICKVL DYIYNWDMCW
KLALIIVVWL LVLFVVLSRS NQALLFRVFC GSQQTPVTRL LVTIMLTALV VLICGFGIGI
CFFYWKKEEN SIMPCGYFYE TILLLSGVNS CANPIICLFV GSIKHCQFQC GTLRLILQRA
IQESPEEEDE EVEEVVEQEG GEEDEESTTL
