ID   MRGB8_RAT               Reviewed;         328 AA.
AC   Q7TN50;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Mas-related G-protein coupled receptor member B8;
GN   Name=Mrgprb8; Synonyms=Mrgb8;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=12909716; DOI=10.1073/pnas.1732949100;
RA   Zylka M.J., Dong X., Southwell A.L., Anderson D.J.;
RT   "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-
RT   coupled receptor family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
CC   -!- FUNCTION: Orphan receptor. Probably involved in the function of
CC       nociceptive neurons. May regulate nociceptor function and/or
CC       development, including the sensation or modulation of pain (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AY266420; AAP20072.1; -; Genomic_DNA.
DR   RefSeq; NP_001002283.1; NM_001002283.1.
DR   AlphaFoldDB; Q7TN50; -.
DR   SMR; Q7TN50; -.
DR   STRING; 10116.ENSRNOP00000065448; -.
DR   GlyGen; Q7TN50; 1 site.
DR   PaxDb; Q7TN50; -.
DR   Ensembl; ENSRNOT00000115775; ENSRNOP00000084983; ENSRNOG00000064327.
DR   GeneID; 404643; -.
DR   KEGG; rno:404643; -.
DR   UCSC; RGD:738051; rat.
DR   CTD; 620137; -.
DR   RGD; 738051; Mrgprb8.
DR   eggNOG; ENOG502RTWA; Eukaryota.
DR   GeneTree; ENSGT01030000234639; -.
DR   InParanoid; Q7TN50; -.
DR   OrthoDB; 1123658at2759; -.
DR   PhylomeDB; Q7TN50; -.
DR   PRO; PR:Q7TN50; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR028328; MRGPCRB8.
DR   InterPro; IPR026234; MRGPCRFAMILY.
DR   PANTHER; PTHR11334; PTHR11334; 1.
DR   PANTHER; PTHR11334:SF8; PTHR11334:SF8; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR02108; MRGPCRFAMILY.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..328
FT                   /note="Mas-related G-protein coupled receptor member B8"
FT                   /id="PRO_0000305304"
FT   TOPO_DOM        1..33
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..62
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        84..112
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        134..144
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        166..178
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        200..224
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        246..263
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        285..328
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        16
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   328 AA;  37041 MW;  802C668A87711A51 CRC64;
     MDSSIPDPEA DLIQLNGSYH TETSPCVIES RVMILLSIII AFFGLAGNAM VLWLLAFRMR
     RNVFSVYILN LAGANFLFLC THTAFSLEKI IVLFHSVHIH IPLLFYTLST LAYLAGVSMV
     TAISAEYWLS GIWPYWYQGQ RLKHTTTVIC TGLWGLALLL SLLEGKSCGF LGSTYNQDVC
     WKLDFIIVAW LLVLFAVLSR SIQVLLVRIF CGSQRTPVTK LHVTIVLTAL VLVICGFPFG
     IIFYLLYWTT EVYYIMPCNS FHETILLLSY INSCANPIIC LLVGSIRHCR FQCGTLRLLL
     HRAMQDIPEE EGEELEEVVG ERVQNSIP