MRGRA_RAT
ID MRGRA_RAT Reviewed; 304 AA.
AC Q7TN49; Q5FVU1; Q91YB7;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Mas-related G-protein coupled receptor member A;
GN Name=Mrgpra; Synonyms=Mrga;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12084918; DOI=10.1073/pnas.122016499;
RA Bender E., Buist A., Jurzak M., Langlois X., Baggerman G., Verhasselt P.,
RA Ercken M., Guo H.-Q., Wintmolders C., Van den Wyngaert I., Van Oers I.,
RA Schoofs L., Luyten W.;
RT "Characterization of an orphan G protein-coupled receptor localized in the
RT dorsal root ganglia reveals adenine as a signaling molecule.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:8573-8578(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley;
RX PubMed=12909716; DOI=10.1073/pnas.1732949100;
RA Zylka M.J., Dong X., Southwell A.L., Anderson D.J.;
RT "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-
RT coupled receptor family.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor activated by a subset of RFamide-family
CC neuropeptides such as FLRF-amide and FMRF-amide. Mediates its action by
CC association with G proteins that activate a phosphatidylinositol-
CC calcium second messenger system. Its effect is mediated by G(q) and
CC G(11) proteins. May regulate the function of nociceptive neurons by
CC modulation of pain perception (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in a subset of IB4-positive small
CC diameter nociceptive dorsal root neurons.
CC {ECO:0000269|PubMed:12909716}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: Was originally thought to be an adenine receptor but
CC PubMed:12397184 found no activation by adenine of the mouse ortholog.
CC {ECO:0000305|PubMed:12084918}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH89774.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAC84592.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ311952; CAC84592.1; ALT_INIT; mRNA.
DR EMBL; AF518238; AAQ08310.1; -; Genomic_DNA.
DR EMBL; BC089774; AAH89774.1; ALT_INIT; mRNA.
DR RefSeq; NP_665730.2; NM_145787.2.
DR AlphaFoldDB; Q7TN49; -.
DR SMR; Q7TN49; -.
DR STRING; 10116.ENSRNOP00000019051; -.
DR PaxDb; Q7TN49; -.
DR PRIDE; Q7TN49; -.
DR GeneID; 252960; -.
DR KEGG; rno:252960; -.
DR CTD; 117195; -.
DR RGD; 738050; Mrgpra.
DR eggNOG; ENOG502RTWA; Eukaryota.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q7TN49; -.
DR OrthoDB; 1123658at2759; -.
DR PhylomeDB; Q7TN49; -.
DR TreeFam; TF336336; -.
DR PRO; PR:Q7TN49; -.
DR Proteomes; UP000002494; Unplaced.
DR Genevisible; Q7TN49; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026233; MRGPCRA.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF33; PTHR11334:SF33; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02109; MRGPCRA.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..304
FT /note="Mas-related G-protein coupled receptor member A"
FT /id="PRO_0000069755"
FT TOPO_DOM 1..17
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..80
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..167
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..211
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..244
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..304
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 11
FT /note="S -> G (in Ref. 1; CAC84592)"
FT /evidence="ECO:0000305"
FT CONFLICT 29
FT /note="I -> T (in Ref. 2; AAQ08310)"
FT /evidence="ECO:0000305"
FT CONFLICT 192
FT /note="L -> S (in Ref. 1; CAC84592)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 304 AA; 34346 MW; 4541FA4B35AC18BF CRC64;
MDKTIPGSFN SRTLIPNLLI IISGLVGLIG NAMVFWLLGF RLARNAFSVY ILNLALADFL
FLLCHIIDST LLLLKFSYPN IIFLPCFNTV MMVPYIAGLS MLSAISTERC LSVVCPIWYR
CRRPKHTSTV MCSAIWVLSL LICILNRYFC GFLDTKYEKD NRCLASNFFT AACLIFLFVV
LCLSSLALLV RLFCGAGRMK LTRLYATIML TVLVFLLCGL PFGIHWFLLI WIKIDYGKFA
YGLYLAALVL TAVNSCANPI IYFFVGSFRH QKHQTLKMVL QRALQDTPET AENTVEMSSS
KVEP
