MRGRD_HUMAN
ID MRGRD_HUMAN Reviewed; 321 AA.
AC Q8TDS7; Q8NGK7;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Mas-related G-protein coupled receptor member D;
DE AltName: Full=Beta-alanine receptor;
DE AltName: Full=G-protein coupled receptor TGR7;
GN Name=MRGPRD; Synonyms=MRGD;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12909716; DOI=10.1073/pnas.1732949100;
RA Zylka M.J., Dong X., Southwell A.L., Anderson D.J.;
RT "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-
RT coupled receptor family.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND POSSIBLE FUNCTION.
RC TISSUE=Liver;
RX PubMed=15037633; DOI=10.1074/jbc.m314240200;
RA Shinohara T., Harada M., Ogi K., Maruyama M., Fujii R., Tanaka H.,
RA Fukusumi S., Komatsu H., Hosoya M., Noguchi Y., Watanabe T., Moriya T.,
RA Itoh Y., Hinuma S.;
RT "Identification of a G protein-coupled receptor specifically responsive to
RT beta-alanine.";
RL J. Biol. Chem. 279:23559-23564(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May regulate nociceptor function and/or development,
CC including the sensation or modulation of pain. Functions as a specific
CC membrane receptor for beta-alanine. Beta-alanine at micromolar doses
CC specifically evoked Ca(2+) influx in cells expressing the receptor.
CC Beta-alanine decreases forskolin-stimulated cAMP production in cells
CC expressing the receptor, suggesting that the receptor couples with G-
CC protein G(q) and G(i).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15037633};
CC Multi-pass membrane protein {ECO:0000269|PubMed:15037633}.
CC Note=Localized at the plasma membrane but internalized into the
CC cytoplasm after treatment with beta-alanine.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC06005.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY427820; AAR05120.1; -; mRNA.
DR EMBL; AB154410; BAD20638.1; -; mRNA.
DR EMBL; AB083627; BAB89340.1; -; Genomic_DNA.
DR EMBL; AB065786; BAC06005.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS31625.1; -.
DR RefSeq; NP_944605.2; NM_198923.2.
DR AlphaFoldDB; Q8TDS7; -.
DR SMR; Q8TDS7; -.
DR STRING; 9606.ENSP00000310631; -.
DR ChEMBL; CHEMBL4523899; -.
DR GuidetoPHARMACOLOGY; 152; -.
DR GlyGen; Q8TDS7; 4 sites.
DR iPTMnet; Q8TDS7; -.
DR PhosphoSitePlus; Q8TDS7; -.
DR BioMuta; MRGPRD; -.
DR DMDM; 50401085; -.
DR PaxDb; Q8TDS7; -.
DR PRIDE; Q8TDS7; -.
DR Antibodypedia; 16747; 107 antibodies from 24 providers.
DR DNASU; 116512; -.
DR Ensembl; ENST00000309106.3; ENSP00000310631.3; ENSG00000172938.3.
DR GeneID; 116512; -.
DR KEGG; hsa:116512; -.
DR MANE-Select; ENST00000309106.3; ENSP00000310631.3; NM_198923.2; NP_944605.2.
DR UCSC; uc010rqf.2; human.
DR CTD; 116512; -.
DR DisGeNET; 116512; -.
DR GeneCards; MRGPRD; -.
DR HGNC; HGNC:29626; MRGPRD.
DR HPA; ENSG00000172938; Not detected.
DR MIM; 607231; gene.
DR neXtProt; NX_Q8TDS7; -.
DR OpenTargets; ENSG00000172938; -.
DR PharmGKB; PA134978563; -.
DR VEuPathDB; HostDB:ENSG00000172938; -.
DR eggNOG; ENOG502SNJC; Eukaryota.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q8TDS7; -.
DR OMA; YWFVLYW; -.
DR OrthoDB; 1015751at2759; -.
DR PhylomeDB; Q8TDS7; -.
DR TreeFam; TF336336; -.
DR PathwayCommons; Q8TDS7; -.
DR SignaLink; Q8TDS7; -.
DR SIGNOR; Q8TDS7; -.
DR BioGRID-ORCS; 116512; 16 hits in 1061 CRISPR screens.
DR GeneWiki; MRGPRD; -.
DR GenomeRNAi; 116512; -.
DR Pharos; Q8TDS7; Tchem.
DR PRO; PR:Q8TDS7; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8TDS7; protein.
DR Bgee; ENSG00000172938; Expressed in mucosa of stomach and 38 other tissues.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026232; MRGPCRD.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02110; MRGPCRD.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..321
FT /note="Mas-related G-protein coupled receptor member D"
FT /id="PRO_0000069756"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..184
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..218
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..257
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..280
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 302..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 321 AA; 36118 MW; B45AB7FEB2154B40 CRC64;
MNQTLNSSGT VESALNYSRG STVHTAYLVL SSLAMFTCLC GMAGNSMVIW LLGFRMHRNP
FCIYILNLAA ADLLFLFSMA STLSLETQPL VNTTDKVHEL MKRLMYFAYT VGLSLLTAIS
TQRCLSVLFP IWFKCHRPRH LSAWVCGLLW TLCLLMNGLT SSFCSKFLKF NEDRCFRVDM
VQAALIMGVL TPVMTLSSLT LFVWVRRSSQ QWRRQPTRLF VVVLASVLVF LICSLPLSIY
WFVLYWLSLP PEMQVLCFSL SRLSSSVSSS ANPVIYFLVG SRRSHRLPTR SLGTVLQQAL
REEPELEGGE TPTVGTNEMG A
