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MRGRD_MACFA
ID   MRGRD_MACFA             Reviewed;         320 AA.
AC   Q6L786; Q5U9D8;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Mas-related G-protein coupled receptor member D;
DE   AltName: Full=Beta-alanine receptor;
DE   AltName: Full=G-protein coupled receptor TGR7;
GN   Name=MRGPRD; Synonyms=MRGD;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=15037633; DOI=10.1074/jbc.m314240200;
RA   Shinohara T., Harada M., Ogi K., Maruyama M., Fujii R., Tanaka H.,
RA   Fukusumi S., Komatsu H., Hosoya M., Noguchi Y., Watanabe T., Moriya T.,
RA   Itoh Y., Hinuma S.;
RT   "Identification of a G protein-coupled receptor specifically responsive to
RT   beta-alanine.";
RL   J. Biol. Chem. 279:23559-23564(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15710235; DOI=10.1016/j.molbrainres.2004.10.007;
RA   Zhang L., Taylor N., Xie Y., Ford R., Johnson J., Paulsen J.E., Bates B.;
RT   "Cloning and expression of MRG receptors in macaque, mouse, and human.";
RL   Brain Res. Mol. Brain Res. 133:187-197(2005).
CC   -!- FUNCTION: May regulate nociceptor function and/or development,
CC       including the sensation or modulation of pain. Functions as a specific
CC       membrane receptor for beta-alanine. The receptor couples with G-protein
CC       G(q) and G(i) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Co-expressed in the small diameter neurons with
CC       P2X3 and VR1 in dorsal root ganglia. {ECO:0000269|PubMed:15037633}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AB154413; BAD20641.1; -; Genomic_DNA.
DR   EMBL; AY772459; AAV49126.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6L786; -.
DR   SMR; Q6L786; -.
DR   STRING; 9541.XP_005577057.1; -.
DR   eggNOG; ENOG502SNJC; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR026232; MRGPCRD.
DR   InterPro; IPR026234; MRGPCRFAMILY.
DR   PANTHER; PTHR11334; PTHR11334; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR02110; MRGPCRD.
DR   PRINTS; PR02108; MRGPCRFAMILY.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..320
FT                   /note="Mas-related G-protein coupled receptor member D"
FT                   /id="PRO_0000069757"
FT   TOPO_DOM        1..33
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..62
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        84..112
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        134..142
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        164..182
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        204..218
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        240..257
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..280
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        281..320
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          301..320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        2
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        16
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        70
FT                   /note="A -> V (in Ref. 2; AAV49126)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        78
FT                   /note="C -> S (in Ref. 2; AAV49126)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        174
FT                   /note="Q -> R (in Ref. 2; AAV49126)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        177
FT                   /note="R -> Q (in Ref. 2; AAV49126)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   320 AA;  35945 MW;  265E137FC7E5481C CRC64;
     MNQTLNSSGT AELALNHSRG SVVHAACLVL SSLAMFTCLC GMAGNSMVIW LLGFRMRRTP
     FSIYILNLAA ADLLFVFCMA AMLSLETQPL VSTTDKVHEL MKRLKYFAYT VGLSLLTAIS
     TQRCLSVLFP IWFKCHRPRH LSAWVCALLW MLCLLTNGLT SCFCSKFLKF NKDQCFRVDM
     VQAALIMGVL TPVMTLSSLT LFVRVRRSSQ QWRRQPTRLF VVVLASVLVF LICSLPLGFY
     WFVLYWLNLP PDTKVLYFNL SRLSSSMSSS ANPLIYFLVG SRRSRRLQGS LGTVLQRALR
     EEPELEGGET PTTGTNEMGA
 
 
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