MRGRD_MACFA
ID MRGRD_MACFA Reviewed; 320 AA.
AC Q6L786; Q5U9D8;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Mas-related G-protein coupled receptor member D;
DE AltName: Full=Beta-alanine receptor;
DE AltName: Full=G-protein coupled receptor TGR7;
GN Name=MRGPRD; Synonyms=MRGD;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=15037633; DOI=10.1074/jbc.m314240200;
RA Shinohara T., Harada M., Ogi K., Maruyama M., Fujii R., Tanaka H.,
RA Fukusumi S., Komatsu H., Hosoya M., Noguchi Y., Watanabe T., Moriya T.,
RA Itoh Y., Hinuma S.;
RT "Identification of a G protein-coupled receptor specifically responsive to
RT beta-alanine.";
RL J. Biol. Chem. 279:23559-23564(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15710235; DOI=10.1016/j.molbrainres.2004.10.007;
RA Zhang L., Taylor N., Xie Y., Ford R., Johnson J., Paulsen J.E., Bates B.;
RT "Cloning and expression of MRG receptors in macaque, mouse, and human.";
RL Brain Res. Mol. Brain Res. 133:187-197(2005).
CC -!- FUNCTION: May regulate nociceptor function and/or development,
CC including the sensation or modulation of pain. Functions as a specific
CC membrane receptor for beta-alanine. The receptor couples with G-protein
CC G(q) and G(i) (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Co-expressed in the small diameter neurons with
CC P2X3 and VR1 in dorsal root ganglia. {ECO:0000269|PubMed:15037633}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB154413; BAD20641.1; -; Genomic_DNA.
DR EMBL; AY772459; AAV49126.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6L786; -.
DR SMR; Q6L786; -.
DR STRING; 9541.XP_005577057.1; -.
DR eggNOG; ENOG502SNJC; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026232; MRGPCRD.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02110; MRGPCRD.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..320
FT /note="Mas-related G-protein coupled receptor member D"
FT /id="PRO_0000069757"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..62
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..182
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..218
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..257
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..280
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..320
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 301..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 70
FT /note="A -> V (in Ref. 2; AAV49126)"
FT /evidence="ECO:0000305"
FT CONFLICT 78
FT /note="C -> S (in Ref. 2; AAV49126)"
FT /evidence="ECO:0000305"
FT CONFLICT 174
FT /note="Q -> R (in Ref. 2; AAV49126)"
FT /evidence="ECO:0000305"
FT CONFLICT 177
FT /note="R -> Q (in Ref. 2; AAV49126)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 320 AA; 35945 MW; 265E137FC7E5481C CRC64;
MNQTLNSSGT AELALNHSRG SVVHAACLVL SSLAMFTCLC GMAGNSMVIW LLGFRMRRTP
FSIYILNLAA ADLLFVFCMA AMLSLETQPL VSTTDKVHEL MKRLKYFAYT VGLSLLTAIS
TQRCLSVLFP IWFKCHRPRH LSAWVCALLW MLCLLTNGLT SCFCSKFLKF NKDQCFRVDM
VQAALIMGVL TPVMTLSSLT LFVRVRRSSQ QWRRQPTRLF VVVLASVLVF LICSLPLGFY
WFVLYWLNLP PDTKVLYFNL SRLSSSMSSS ANPLIYFLVG SRRSRRLQGS LGTVLQRALR
EEPELEGGET PTTGTNEMGA