MRGRD_MOUSE
ID MRGRD_MOUSE Reviewed; 321 AA.
AC Q91ZB8;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Mas-related G-protein coupled receptor member D;
DE AltName: Full=Beta-alanine receptor;
DE AltName: Full=G-protein coupled receptor TGR7;
GN Name=Mrgprd; Synonyms=Gm499, Mrgd;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=11551509; DOI=10.1016/s0092-8674(01)00483-4;
RA Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.;
RT "A diverse family of GPCRs expressed in specific subsets of nociceptive
RT sensory neurons.";
RL Cell 106:619-632(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15037633; DOI=10.1074/jbc.m314240200;
RA Shinohara T., Harada M., Ogi K., Maruyama M., Fujii R., Tanaka H.,
RA Fukusumi S., Komatsu H., Hosoya M., Noguchi Y., Watanabe T., Moriya T.,
RA Itoh Y., Hinuma S.;
RT "Identification of a G protein-coupled receptor specifically responsive to
RT beta-alanine.";
RL J. Biol. Chem. 279:23559-23564(2004).
CC -!- FUNCTION: May regulate nociceptor function and/or development,
CC including the sensation or modulation of pain. Functions as a specific
CC membrane receptor for beta-alanine. The receptor couples with G-protein
CC G(q) and G(i) (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in a subset of sensory neurons that
CC includes nociceptors. Expressed in the subclass of non-peptidergic
CC sensory neurons that are IB4(+) and VR1(-).
CC {ECO:0000269|PubMed:11551509}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY042209; AAK91800.1; -; Genomic_DNA.
DR EMBL; AB154412; BAD20640.1; -; Genomic_DNA.
DR CCDS; CCDS22057.1; -.
DR RefSeq; NP_987075.1; NM_203490.3.
DR AlphaFoldDB; Q91ZB8; -.
DR SMR; Q91ZB8; -.
DR STRING; 10090.ENSMUSP00000063021; -.
DR GuidetoPHARMACOLOGY; 152; -.
DR GlyGen; Q91ZB8; 1 site.
DR PhosphoSitePlus; Q91ZB8; -.
DR PaxDb; Q91ZB8; -.
DR PRIDE; Q91ZB8; -.
DR ProteomicsDB; 290315; -.
DR Antibodypedia; 16747; 107 antibodies from 24 providers.
DR DNASU; 211578; -.
DR Ensembl; ENSMUST00000062163; ENSMUSP00000063021; ENSMUSG00000051207.
DR GeneID; 211578; -.
DR KEGG; mmu:211578; -.
DR UCSC; uc009kra.1; mouse.
DR CTD; 116512; -.
DR MGI; MGI:3033142; Mrgprd.
DR VEuPathDB; HostDB:ENSMUSG00000051207; -.
DR eggNOG; ENOG502SNJC; Eukaryota.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q91ZB8; -.
DR OMA; YWFVLYW; -.
DR OrthoDB; 1015751at2759; -.
DR PhylomeDB; Q91ZB8; -.
DR TreeFam; TF336336; -.
DR BioGRID-ORCS; 211578; 13 hits in 72 CRISPR screens.
DR PRO; PR:Q91ZB8; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q91ZB8; protein.
DR Bgee; ENSMUSG00000051207; Expressed in presumptive midbrain and 14 other tissues.
DR ExpressionAtlas; Q91ZB8; differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026232; MRGPCRD.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02110; MRGPCRD.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..321
FT /note="Mas-related G-protein coupled receptor member D"
FT /id="PRO_0000069758"
FT TOPO_DOM 1..8
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 9..29
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..72
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..181
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..220
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..260
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 302..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 321 AA; 36126 MW; B0642547A75077B3 CRC64;
MNSTLDSSPA PGLTISPTMD LVTWIYFSVT FLAMATCVGG MAGNSLVIWL LSCNGMQRSP
FCVYVLNLAV ADFLFLFCMA SMLSLETGPL LIVNISAKIY EGMRRIKYFA YTAGLSLLTA
ISTQRCLSVL FPIWYKCHRP RHLSSVVSGA LWALAFLMNF LASFFCVQFW HPNKHQCFKV
DIVFNSLILG IFMPVMILTS TILFIRVRKN SLMQRRRPRR LYVVILTSIL VFLTCSLPLG
INWFLLYWVD VKRDVRLLYS CVSRFSSSLS SSANPVIYFL VGSQKSHRLQ ESLGAVLGRA
LRDEPEPEGR ETPSTCTNDG V
