MRGRD_RAT
ID MRGRD_RAT Reviewed; 319 AA.
AC Q7TN41; Q6L788;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Mas-related G-protein coupled receptor member D;
DE AltName: Full=Beta-alanine receptor;
DE AltName: Full=G-protein coupled receptor TGR7;
GN Name=Mrgprd; Synonyms=Mrgd;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sprague-Dawley;
RX PubMed=12909716; DOI=10.1073/pnas.1732949100;
RA Zylka M.J., Dong X., Southwell A.L., Anderson D.J.;
RT "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-
RT coupled receptor family.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Cerebellum;
RX PubMed=15037633; DOI=10.1074/jbc.m314240200;
RA Shinohara T., Harada M., Ogi K., Maruyama M., Fujii R., Tanaka H.,
RA Fukusumi S., Komatsu H., Hosoya M., Noguchi Y., Watanabe T., Moriya T.,
RA Itoh Y., Hinuma S.;
RT "Identification of a G protein-coupled receptor specifically responsive to
RT beta-alanine.";
RL J. Biol. Chem. 279:23559-23564(2004).
CC -!- FUNCTION: May regulate nociceptor function and/or development,
CC including the sensation or modulation of pain. Functions as a specific
CC membrane receptor for beta-alanine. The receptor couples with G-protein
CC G(q) and G(i) (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Co-expressed in the small diameter neurons with
CC P2X3 and VR1 in dorsal root ganglia. {ECO:0000269|PubMed:15037633}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF518246; AAQ08318.1; -; Genomic_DNA.
DR EMBL; AB154411; BAD20639.1; -; mRNA.
DR RefSeq; NP_001001506.1; NM_001001506.1.
DR RefSeq; XP_006230787.1; XM_006230725.3.
DR AlphaFoldDB; Q7TN41; -.
DR SMR; Q7TN41; -.
DR STRING; 10116.ENSRNOP00000017958; -.
DR GuidetoPHARMACOLOGY; 152; -.
DR PhosphoSitePlus; Q7TN41; -.
DR PaxDb; Q7TN41; -.
DR PRIDE; Q7TN41; -.
DR Ensembl; ENSRNOT00000017958; ENSRNOP00000017958; ENSRNOG00000013448.
DR GeneID; 293648; -.
DR KEGG; rno:293648; -.
DR UCSC; RGD:738040; rat.
DR CTD; 116512; -.
DR RGD; 738040; Mrgprd.
DR eggNOG; ENOG502SNJC; Eukaryota.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q7TN41; -.
DR OMA; YWFVLYW; -.
DR OrthoDB; 1015751at2759; -.
DR PhylomeDB; Q7TN41; -.
DR TreeFam; TF336336; -.
DR PRO; PR:Q7TN41; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000013448; Expressed in testis.
DR ExpressionAtlas; Q7TN41; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026232; MRGPCRD.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02110; MRGPCRD.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..319
FT /note="Mas-related G-protein coupled receptor member D"
FT /id="PRO_0000069759"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..64
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..92
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..184
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..220
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..260
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 55
FT /note="R -> S (in Ref. 2; BAD20639)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 319 AA; 35830 MW; 500F41492DE002F7 CRC64;
MNYTPYSSPA PGLTISPTMD PVTWVYFSVT FLAMATCVCG IVGNSMVIWL LSFHRVQRSP
FCTYVLNLAV ADLLFLLCMA SLLSLETGPL LTASTSARVY EGMKRIKYFA YTAGLSLLTA
ISTQRCLSVL FPIWYKCHRP QHLSGVVCGV LWALALLMNF LASFFCVQFW HPDKYQCFKV
DMVFNSLILG IFMPVMVLTS AIIFIRMRKN SLLQRRQPRR LYVVILTSVL VFLTCSLPLG
INWFLLYWVE LPQAVRLLYV CSSRFSSSLS SSANPVIYFL VGSQKSHRLQ ESLGAVLGRA
LQDEPEGRET PSTCTNDGV
