MRGRE_HUMAN
ID MRGRE_HUMAN Reviewed; 312 AA.
AC Q86SM8; Q2M1V7;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 09-JUL-2014, sequence version 3.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Mas-related G-protein coupled receptor member E;
DE AltName: Full=G-protein coupled receptor 167;
GN Name=MRGPRE; Synonyms=GPR167, MRGE;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 58-202.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC -!- FUNCTION: Orphan receptor. May regulate nociceptor function and/or
CC development, including the sensation or modulation of pain.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI04890.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI12204.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BC104889; AAI04890.1; ALT_INIT; mRNA.
DR EMBL; BC112203; AAI12204.1; ALT_INIT; mRNA.
DR EMBL; AY255572; AAO85084.1; -; mRNA.
DR CCDS; CCDS41603.2; -.
DR RefSeq; NP_001034254.2; NM_001039165.2.
DR AlphaFoldDB; Q86SM8; -.
DR SMR; Q86SM8; -.
DR BioGRID; 125519; 1.
DR STRING; 9606.ENSP00000374482; -.
DR ChEMBL; CHEMBL4523882; -.
DR PhosphoSitePlus; Q86SM8; -.
DR BioMuta; MRGPRE; -.
DR DMDM; 115502418; -.
DR PaxDb; Q86SM8; -.
DR PeptideAtlas; Q86SM8; -.
DR PRIDE; Q86SM8; -.
DR ProteomicsDB; 69602; -.
DR Antibodypedia; 23328; 107 antibodies from 23 providers.
DR DNASU; 116534; -.
DR Ensembl; ENST00000389832.7; ENSP00000374482.6; ENSG00000184350.11.
DR GeneID; 116534; -.
DR KEGG; hsa:116534; -.
DR MANE-Select; ENST00000389832.7; ENSP00000374482.6; NM_001039165.4; NP_001034254.2.
DR CTD; 116534; -.
DR GeneCards; MRGPRE; -.
DR HGNC; HGNC:30694; MRGPRE.
DR HPA; ENSG00000184350; Tissue enriched (brain).
DR MIM; 607232; gene.
DR neXtProt; NX_Q86SM8; -.
DR OpenTargets; ENSG00000184350; -.
DR PharmGKB; PA134939296; -.
DR VEuPathDB; HostDB:ENSG00000184350; -.
DR eggNOG; ENOG502TKZN; Eukaryota.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q86SM8; -.
DR OMA; PFGIYWL; -.
DR OrthoDB; 1123658at2759; -.
DR PhylomeDB; Q86SM8; -.
DR TreeFam; TF336336; -.
DR PathwayCommons; Q86SM8; -.
DR BioGRID-ORCS; 116534; 15 hits in 961 CRISPR screens.
DR GeneWiki; MRGPRE; -.
DR GenomeRNAi; 116534; -.
DR Pharos; Q86SM8; Tbio.
DR PRO; PR:Q86SM8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q86SM8; protein.
DR Bgee; ENSG00000184350; Expressed in dorsal root ganglion and 92 other tissues.
DR ExpressionAtlas; Q86SM8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026230; MRGPCRE.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF26; PTHR11334:SF26; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02111; MRGPCRE.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Mas-related G-protein coupled receptor member E"
FT /id="PRO_0000069760"
FT TOPO_DOM 1..20
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..176
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..217
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 239..241
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VARIANT 16
FT /note="G -> S (in dbSNP:rs12295710)"
FT /id="VAR_059325"
FT VARIANT 160
FT /note="G -> S (in dbSNP:rs4391795)"
FT /id="VAR_059326"
SQ SEQUENCE 312 AA; 34286 MW; 42CC3B3C8D1AF974 CRC64;
MMEPREAGQH VGAANGAQED VAFNLIILSL TEGLGLGGLL GNGAVLWLLS SNVYRNPFAI
YLLDVACADL IFLGCHMVAI VPDLLQGRLD FPGFVQTSLA TLRFFCYIVG LSLLAAVSVE
QCLAALFPAW YSCRRPRHLT TCVCALTWAL CLLLHLLLSG ACTQFFGEPS RHLCRTLWLV
AAVLLALLCC TMCGASLMLL LRVERGPQRP PPRGFPGLIL LTVLLFLFCG LPFGIYWLSR
NLLWYIPHYF YHFSFLMAAV HCAAKPVVYF CLGSAQGRRL PLRLVLQRAL GDEAELGAVR
ETSRRGLVDI AA
