ID   MRGRE_MACFA             Reviewed;         311 AA.
AC   Q5U9D7;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Mas-related G-protein coupled receptor member E;
GN   Name=MRGPRE; Synonyms=MRGE;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15710235; DOI=10.1016/j.molbrainres.2004.10.007;
RA   Zhang L., Taylor N., Xie Y., Ford R., Johnson J., Paulsen J.E., Bates B.;
RT   "Cloning and expression of MRG receptors in macaque, mouse, and human.";
RL   Brain Res. Mol. Brain Res. 133:187-197(2005).
CC   -!- FUNCTION: Orphan receptor. May regulate nociceptor function and/or
CC       development, including the sensation or modulation of pain.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY772460; AAV49127.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5U9D7; -.
DR   SMR; Q5U9D7; -.
DR   STRING; 9541.XP_005576988.1; -.
DR   eggNOG; ENOG502TKZN; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR026230; MRGPCRE.
DR   InterPro; IPR026234; MRGPCRFAMILY.
DR   PANTHER; PTHR11334; PTHR11334; 1.
DR   PANTHER; PTHR11334:SF26; PTHR11334:SF26; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR02111; MRGPCRE.
DR   PRINTS; PR02108; MRGPCRFAMILY.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..311
FT                   /note="Mas-related G-protein coupled receptor member E"
FT                   /id="PRO_0000069761"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..63
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        85..95
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        117..136
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        158..177
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        199..216
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..237
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        238..251
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        273..311
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   311 AA;  34087 MW;  B0073B60521CE9E5 CRC64;
     MEPREAGQHA GAADGAQEDV AFNLVILSLT EGLGLGGLLG NGAVLWLLSS NVYRNPFAIY
     LLDVACADLI FLGCHMVAII PDLLQGRLDF PGFVQTSLAT LRFFCYIVGL SLLVAVSVEQ
     CLAALFPAWY SCRRPRHLTT CVCALTWACC LLLHLLLSGA CTQFFGEPSR HLCRTLWLVA
     AVLLAVLCCT MCGASLMLLL QVERGPQRPP PRGFPTLILL AVLLFLFCGL PFGIYWLSRN
     LLWHIPHYFY HFSFLTAAVY CAAKPVVYFC LGSAQGRRLP LRLVLQRALG DEAELGAVRE
     TSRRGLVDIA A