MRGRE_MOUSE
ID MRGRE_MOUSE Reviewed; 310 AA.
AC Q91ZB7; Q711I9;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Mas-related G-protein coupled receptor member E;
DE AltName: Full=Evolutionary breakpoint transcript 3 protein;
GN Name=Mrgpre; Synonyms=Ebrt3, Mrge;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J;
RX PubMed=11551509; DOI=10.1016/s0092-8674(01)00483-4;
RA Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.;
RT "A diverse family of GPCRs expressed in specific subsets of nociceptive
RT sensory neurons.";
RL Cell 106:619-632(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J;
RA Engemann S., Stroedicke M., Meguro M., Franck O., Kalscheuer V.,
RA Oshimura M., Walter J.;
RT "An evolutionary breakpoint region borders the imprinted Beckwith-Wiedemann
RT syndrome (BWS) region.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Orphan receptor. May regulate nociceptor function and/or
CC development, including the sensation or modulation of pain.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY042210; AAK91801.1; -; Genomic_DNA.
DR EMBL; AJ320231; CAC86257.1; -; mRNA.
DR EMBL; AK048528; BAC33361.1; -; mRNA.
DR CCDS; CCDS22046.1; -.
DR RefSeq; NP_780743.1; NM_175534.3.
DR AlphaFoldDB; Q91ZB7; -.
DR SMR; Q91ZB7; -.
DR STRING; 10090.ENSMUSP00000058000; -.
DR GlyGen; Q91ZB7; 2 sites.
DR PhosphoSitePlus; Q91ZB7; -.
DR PaxDb; Q91ZB7; -.
DR PRIDE; Q91ZB7; -.
DR ProteomicsDB; 290316; -.
DR Antibodypedia; 23328; 107 antibodies from 23 providers.
DR DNASU; 244238; -.
DR Ensembl; ENSMUST00000054048; ENSMUSP00000058000; ENSMUSG00000048965.
DR GeneID; 244238; -.
DR KEGG; mmu:244238; -.
DR UCSC; uc009kpz.2; mouse.
DR CTD; 116534; -.
DR MGI; MGI:2441884; Mrgpre.
DR VEuPathDB; HostDB:ENSMUSG00000048965; -.
DR eggNOG; ENOG502TKZN; Eukaryota.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q91ZB7; -.
DR OMA; PFGIYWL; -.
DR OrthoDB; 1123658at2759; -.
DR PhylomeDB; Q91ZB7; -.
DR TreeFam; TF336336; -.
DR BioGRID-ORCS; 244238; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Mrgpre; mouse.
DR PRO; PR:Q91ZB7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q91ZB7; protein.
DR Bgee; ENSMUSG00000048965; Expressed in lumbar dorsal root ganglion and 105 other tissues.
DR ExpressionAtlas; Q91ZB7; baseline and differential.
DR Genevisible; Q91ZB7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026230; MRGPCRE.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF26; PTHR11334:SF26; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02111; MRGPCRE.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..310
FT /note="Mas-related G-protein coupled receptor member E"
FT /id="PRO_0000069762"
FT TOPO_DOM 1..22
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..92
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..174
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..213
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..248
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 237
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 310 AA; 34588 MW; 9E44127DCB5E9370 CRC64;
MTSLSVHTDS PSTQGEMAFN LTILSLTELL SLGGLLGNGV ALWLLNQNVY RNPFSIYLLD
VACADLIFLC CHMVAIIPEL LQDQLNFPEF VHISLTMLRF FCYIVGLSLL AAISTEQCLA
TLFPAWYLCR RPRYLTTCVC ALIWVLCLLL DLLLSGACTQ FFGAPSYHLC DMLWLVVAVL
LAALCCTMCV TSLLLLLRVE RGPERHQPRG FPTLVLLAVL LFLFCGLPFG IFWLSKNLSW
HIPLYFYHFS FFMASVHSAA KPAIYFFLGS TPGQRFREPL RLVLQRALGD EAELGAGREA
SQGGLVDMTV
