MRGRE_RAT
ID MRGRE_RAT Reviewed; 309 AA.
AC Q7TN40;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Mas-related G-protein coupled receptor member E;
GN Name=Mrgpre; Synonyms=Mrge;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=12909716; DOI=10.1073/pnas.1732949100;
RA Zylka M.J., Dong X., Southwell A.L., Anderson D.J.;
RT "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-
RT coupled receptor family.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
CC -!- FUNCTION: Orphan receptor. May regulate nociceptor function and/or
CC development, including the sensation or modulation of pain.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF518247; AAQ08319.1; -; Genomic_DNA.
DR RefSeq; NP_001002288.1; NM_001002288.1.
DR RefSeq; XP_006230932.1; XM_006230870.3.
DR RefSeq; XP_006230934.1; XM_006230872.3.
DR RefSeq; XP_008758385.1; XM_008760163.2.
DR RefSeq; XP_017445008.1; XM_017589519.1.
DR RefSeq; XP_017445009.1; XM_017589520.1.
DR AlphaFoldDB; Q7TN40; -.
DR SMR; Q7TN40; -.
DR GlyGen; Q7TN40; 2 sites.
DR iPTMnet; Q7TN40; -.
DR PhosphoSitePlus; Q7TN40; -.
DR Ensembl; ENSRNOT00000094719; ENSRNOP00000093679; ENSRNOG00000065330.
DR Ensembl; ENSRNOT00000109796; ENSRNOP00000079771; ENSRNOG00000065330.
DR Ensembl; ENSRNOT00000115771; ENSRNOP00000089804; ENSRNOG00000065330.
DR GeneID; 404660; -.
DR KEGG; rno:404660; -.
DR UCSC; RGD:738045; rat.
DR CTD; 116534; -.
DR RGD; 738045; Mrgpre.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q7TN40; -.
DR OMA; PFGIYWL; -.
DR OrthoDB; 1123658at2759; -.
DR PhylomeDB; Q7TN40; -.
DR TreeFam; TF336336; -.
DR PRO; PR:Q7TN40; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000054917; Expressed in frontal cortex and 6 other tissues.
DR ExpressionAtlas; Q7TN40; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026230; MRGPCRE.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF26; PTHR11334:SF26; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02111; MRGPCRE.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..309
FT /note="Mas-related G-protein coupled receptor member E"
FT /id="PRO_0000069763"
FT TOPO_DOM 1..21
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..42
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..91
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..168
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..212
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..247
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 236
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 309 AA; 34511 MW; 20F0424940FB9781 CRC64;
MSLRVHTHSP STQGDMAFNL TILSLTELLS LGGLLGNGVA LWLLNQNVYR NPFSIYLLDV
ACADLIFLCC HMVAIIPELL QDQLNFPEFV HISLIMLRFF CYIVGLSLLV AISTEQCLAT
LFPSGYLCRR PRYLTTCVCA FIWVLCLLLD LLLSGACTQF FGAPSYHLCG MLWLVVAVLL
AALCCTMCVT SLLLLLRVER GPERHQPRGF PTLVLLVILL FLFCGLPFGI FWLSKNLSWH
TPLYFYHFSF FMASVHSAAK PAIYFFLGST PGQRFQEPLR LVLQRALGDE AELGAVREAS
QGGLVDMTV
