MRGRF_MOUSE
ID MRGRF_MOUSE Reviewed; 343 AA.
AC Q8VCJ6; Q91ZB6;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Mas-related G-protein coupled receptor member F;
DE Short=Mas-related gene F protein;
GN Name=Mrgprf; Synonyms=Mrgf;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-343.
RC STRAIN=C57BL/6J;
RX PubMed=11551509; DOI=10.1016/s0092-8674(01)00483-4;
RA Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.;
RT "A diverse family of GPCRs expressed in specific subsets of nociceptive
RT sensory neurons.";
RL Cell 106:619-632(2001).
CC -!- FUNCTION: Orphan receptor. May bind to a neuropeptide and may regulate
CC nociceptor function and/or development, including the sensation or
CC modulation of pain.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; BC019711; AAH19711.1; -; mRNA.
DR EMBL; AY042211; AAK91802.1; -; Genomic_DNA.
DR CCDS; CCDS22056.1; -.
DR RefSeq; NP_663354.1; NM_145379.2.
DR AlphaFoldDB; Q8VCJ6; -.
DR SMR; Q8VCJ6; -.
DR STRING; 10090.ENSMUSP00000033386; -.
DR GlyGen; Q8VCJ6; 1 site.
DR PhosphoSitePlus; Q8VCJ6; -.
DR MaxQB; Q8VCJ6; -.
DR PaxDb; Q8VCJ6; -.
DR PRIDE; Q8VCJ6; -.
DR ProteomicsDB; 290317; -.
DR Antibodypedia; 16748; 282 antibodies from 30 providers.
DR DNASU; 211577; -.
DR Ensembl; ENSMUST00000033386; ENSMUSP00000033386; ENSMUSG00000031070.
DR GeneID; 211577; -.
DR KEGG; mmu:211577; -.
DR UCSC; uc009kqz.1; mouse.
DR CTD; 116535; -.
DR MGI; MGI:2384823; Mrgprf.
DR VEuPathDB; HostDB:ENSMUSG00000031070; -.
DR eggNOG; ENOG502SIXZ; Eukaryota.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q8VCJ6; -.
DR OMA; RILGLCM; -.
DR OrthoDB; 835806at2759; -.
DR PhylomeDB; Q8VCJ6; -.
DR TreeFam; TF336336; -.
DR BioGRID-ORCS; 211577; 5 hits in 72 CRISPR screens.
DR PRO; PR:Q8VCJ6; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8VCJ6; protein.
DR Bgee; ENSMUSG00000031070; Expressed in vault of skull and 76 other tissues.
DR ExpressionAtlas; Q8VCJ6; baseline and differential.
DR Genevisible; Q8VCJ6; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026228; MRGPCRF.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF3; PTHR11334:SF3; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02112; MRGPCRF.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..343
FT /note="Mas-related G-protein coupled receptor member F"
FT /id="PRO_0000069765"
FT TOPO_DOM 1..44
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..66
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..104
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..123
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..160
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..343
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 318..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 343 AA; 38523 MW; 358ED59587C9A317 CRC64;
MAGNCSWEAH STNQNKMCPG MSEARELYSR GFLTIEQIAT LPPPAVTNYI FLLLCLCGLV
GNGLVLWFFG FSIKRTPFSI YFLHLASADG MYLFSKAVIA LLNMGTFLGS FPDYIRRVSR
IVGLCTFFTG VSLLPAISIE RCVSVIFPTW YWRRRPKRLS AGVCALLWML SFLVTSIHNY
FCMFLGHEAP GTVCRNMDIA LGILLFFLFC PLMVLPCLAL ILHVECRARR RQRSAKLNHV
VLAIVSVFLV SSIYLGIDWF LFWVFQIPAP FPEYVTDLCI CINSSAKPIV YFLAGRDKSQ
RLWEPLRVVF QRALRDGAEP GDAASSTPNT VTMEMQCPSG NAS
