MRGRF_RAT
ID MRGRF_RAT Reviewed; 343 AA.
AC P23749;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=Mas-related G-protein coupled receptor member F;
DE Short=Mas-related gene F protein;
DE AltName: Full=G-protein coupled receptor RTA;
GN Name=Mrgprf; Synonyms=Mrgf, Rta;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Aorta;
RX PubMed=2109324; DOI=10.1073/pnas.87.8.3052;
RA Ross P.C., Figler R.A., Corjay M.H., Barber C.M., Adam N., Harcus D.R.,
RA Lynch K.R.;
RT "RTA, a candidate G protein-coupled receptor: cloning, sequencing, and
RT tissue distribution.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:3052-3056(1990).
CC -!- FUNCTION: Orphan receptor. May bind to a neuropeptide and may regulate
CC nociceptor function and/or development, including the sensation or
CC modulation of pain (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Gut, vas deferens, uterus and aorta; barely
CC detectable in liver, kidney, lung, and salivary gland. In the brain,
CC markedly abundant in the cerebellum.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; M35297; AAA42087.1; -; mRNA.
DR EMBL; M35298; AAA42088.1; -; Genomic_DNA.
DR PIR; A35639; A35639.
DR RefSeq; NP_714944.1; NM_153722.2.
DR AlphaFoldDB; P23749; -.
DR SMR; P23749; -.
DR STRING; 10116.ENSRNOP00000017948; -.
DR GlyGen; P23749; 1 site.
DR PhosphoSitePlus; P23749; -.
DR PaxDb; P23749; -.
DR PRIDE; P23749; -.
DR GeneID; 266762; -.
DR KEGG; rno:266762; -.
DR UCSC; RGD:708478; rat.
DR CTD; 116535; -.
DR RGD; 708478; Mrgprf.
DR eggNOG; ENOG502SIXZ; Eukaryota.
DR InParanoid; P23749; -.
DR PhylomeDB; P23749; -.
DR PRO; PR:P23749; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026228; MRGPCRF.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF3; PTHR11334:SF3; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02112; MRGPCRF.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..343
FT /note="Mas-related G-protein coupled receptor member F"
FT /id="PRO_0000069766"
FT TOPO_DOM 1..44
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..66
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..104
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..123
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..160
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..343
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 318..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 343 AA; 38364 MW; E4630007770941F4 CRC64;
MAGNCSWEAH STNQNKMCPG MSEALELYSR GFLTIEQIAT LPPPAVTNYI FLLLCLCGLV
GNGLVLWFFG FSIKRTPFSI YFLHLASADG IYLFSKAVIA LLNMGTFLGS FPDYVRRVSR
IVGLCTFFAG VSLLPAISIE RCVSVIFPMW YWRRRPKRLS AGVCALLWLL SFLVTSIHNY
FCMFLGHEAS GTACLNMDIS LGILLFFLFC PLMVLPCLAL ILHVECRARR RQRSAKLNHV
VLAIVSVFLV SSIYLGIDWF LFWVFQIPAP FPEYVTDLCI CINSSAKPIV YFLAGRDKSQ
RLWEPLRVVF QRALRDGAEP GDAASSTPNT VTMEMQCPSG NAS
