MRGRG_HUMAN
ID MRGRG_HUMAN Reviewed; 289 AA.
AC Q86SM5;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Mas-related G-protein coupled receptor member G;
DE AltName: Full=G-protein coupled receptor 169;
GN Name=MRGPRG; Synonyms=GPR169, MRGG;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-54.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC -!- FUNCTION: Orphan receptor. May regulate nociceptor function and/or
CC development, including the sensation or modulation of pain (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AC109309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY255583; AAO85095.1; -; mRNA.
DR CCDS; CCDS44520.1; -.
DR RefSeq; NP_001157849.1; NM_001164377.1.
DR AlphaFoldDB; Q86SM5; -.
DR SMR; Q86SM5; -.
DR STRING; 9606.ENSP00000330612; -.
DR ChEMBL; CHEMBL4523881; -.
DR BioMuta; MRGPRG; -.
DR DMDM; 115502419; -.
DR PaxDb; Q86SM5; -.
DR PRIDE; Q86SM5; -.
DR Antibodypedia; 23325; 52 antibodies from 15 providers.
DR DNASU; 386746; -.
DR Ensembl; ENST00000332314.3; ENSP00000330612.3; ENSG00000182170.3.
DR GeneID; 386746; -.
DR KEGG; hsa:386746; -.
DR MANE-Select; ENST00000332314.3; ENSP00000330612.3; NM_001164377.1; NP_001157849.1.
DR UCSC; uc001lxp.2; human.
DR CTD; 386746; -.
DR GeneCards; MRGPRG; -.
DR HGNC; HGNC:24829; MRGPRG.
DR HPA; ENSG00000182170; Not detected.
DR MIM; 607234; gene.
DR neXtProt; NX_Q86SM5; -.
DR PharmGKB; PA134953683; -.
DR VEuPathDB; HostDB:ENSG00000182170; -.
DR eggNOG; ENOG502TKZP; Eukaryota.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q86SM5; -.
DR OMA; NGLVLWH; -.
DR OrthoDB; 1180963at2759; -.
DR PhylomeDB; Q86SM5; -.
DR TreeFam; TF336336; -.
DR PathwayCommons; Q86SM5; -.
DR SignaLink; Q86SM5; -.
DR BioGRID-ORCS; 386746; 21 hits in 1061 CRISPR screens.
DR GeneWiki; MRGPRG; -.
DR GenomeRNAi; 386746; -.
DR Pharos; Q86SM5; Tdark.
DR PRO; PR:Q86SM5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q86SM5; protein.
DR Bgee; ENSG00000182170; Expressed in testis and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd15111; 7tmA_MrgprG; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR InterPro; IPR027336; MRGPCRG.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF32; PTHR11334:SF32; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..289
FT /note="Mas-related G-protein coupled receptor member G"
FT /id="PRO_0000069767"
FT TOPO_DOM 1..13
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..42
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..78
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..120
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..163
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..195
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..221
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 243..289
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 289 AA; 31518 MW; DE8457DC94F3E2C6 CRC64;
MFGLFGLWRT FDSVVFYLTL IVGLGGPVGN GLVLWNLGFR IKKGPFSIYL LHLAAADFLF
LSCRVGFSVA QAALGAQDTL YFVLTFLWFA VGLWLLAAFS VERCLSDLFP ACYQGCRPRH
ASAVLCALVW TPTLPAVPLP ANACGLLRNS ACPLVCPRYH VASVTWFLVL ARVAWTAGVV
LFVWVTCCST RPRPRLYGIV LGALLLLFFC GLPSVFYWSL QPLLNFLLPV FSPLATLLAC
VNSSSKPLIY SGLGRQPGKR EPLRSVLRRA LGEGAELGAR GQSLPMGLL
