MRGRG_MOUSE
ID MRGRG_MOUSE Reviewed; 289 AA.
AC Q91ZB5; Q498A2; Q711N2;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Mas-related G-protein coupled receptor member G;
DE AltName: Full=Evolutionary breakpoint transcript 2 protein;
GN Name=Mrgprg; Synonyms=Ebrt2, Gm1098, Mrgg;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=11551509; DOI=10.1016/s0092-8674(01)00483-4;
RA Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.;
RT "A diverse family of GPCRs expressed in specific subsets of nociceptive
RT sensory neurons.";
RL Cell 106:619-632(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-156.
RC STRAIN=C57BL/6J;
RA Engemann S., Stroedicke M., Meguro M., Franck O., Kalscheuer V.,
RA Oshimura M., Walter J.;
RT "The BWS region contains an evolutionary breakpoint region.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Orphan receptor. May regulate nociceptor function and/or
CC development, including the sensation or modulation of pain.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000305}.
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DR EMBL; AY042212; AAK91803.1; -; Genomic_DNA.
DR EMBL; BC100302; AAI00303.1; -; mRNA.
DR EMBL; AJ313465; CAC86130.1; -; mRNA.
DR CCDS; CCDS22045.1; -.
DR RefSeq; NP_987077.1; NM_203492.2.
DR AlphaFoldDB; Q91ZB5; -.
DR SMR; Q91ZB5; -.
DR STRING; 10090.ENSMUSP00000060411; -.
DR PaxDb; Q91ZB5; -.
DR PRIDE; Q91ZB5; -.
DR ProteomicsDB; 291508; -.
DR Antibodypedia; 23325; 52 antibodies from 15 providers.
DR DNASU; 381974; -.
DR Ensembl; ENSMUST00000058092; ENSMUSP00000060411; ENSMUSG00000050276.
DR GeneID; 381974; -.
DR KEGG; mmu:381974; -.
DR UCSC; uc009kpy.1; mouse.
DR CTD; 386746; -.
DR MGI; MGI:3033145; Mrgprg.
DR VEuPathDB; HostDB:ENSMUSG00000050276; -.
DR eggNOG; ENOG502TKZP; Eukaryota.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q91ZB5; -.
DR OMA; NGLVLWH; -.
DR OrthoDB; 1180963at2759; -.
DR PhylomeDB; Q91ZB5; -.
DR TreeFam; TF336336; -.
DR BioGRID-ORCS; 381974; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Mrgprg; mouse.
DR PRO; PR:Q91ZB5; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q91ZB5; protein.
DR Bgee; ENSMUSG00000050276; Expressed in decidua and 11 other tissues.
DR ExpressionAtlas; Q91ZB5; baseline and differential.
DR Genevisible; Q91ZB5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd15111; 7tmA_MrgprG; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR InterPro; IPR027336; MRGPCRG.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF32; PTHR11334:SF32; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02108; MRGPCRFAMILY.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..289
FT /note="Mas-related G-protein coupled receptor member G"
FT /id="PRO_0000069768"
FT TOPO_DOM 1..13
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..78
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..120
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..164
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..199
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..222
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..289
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 122
FT /note="T -> I (in Ref. 3; CAC86130)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 289 AA; 32028 MW; 82BD4BEA02E0864C CRC64;
MFSIFNIWGT FNKVLFFLSL TVSLAGLVGN ALLLWHLGLH IKKGPFNTYL LHLAAADFLF
LSCQVGFSIA TIVSGHEDTL YFPVTFLWFA VGLWLLAAFS VDCCLAYMFP SFCSPNRRPR
FTSVVLCLVI WALTMPAVLL PANACGLLKN GMSLLVCLKY HWTSVTWLAV LSGMACGASK
FLLIFGNCCS SQPPPKFCKL AQCSGILLFF CRLPLVVYWC LRPVLKFLLP FFFPLATLLA
CIDSSAKPLL YYMKGRQLRK DPLQVALNRA LGEESQSGLG GLSLPMHQV
