MRGRG_RAT
ID MRGRG_RAT Reviewed; 289 AA.
AC Q7TN39;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Mas-related G-protein coupled receptor member G;
GN Name=Mrgprg; Synonyms=Mrgg;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=12909716; DOI=10.1073/pnas.1732949100;
RA Zylka M.J., Dong X., Southwell A.L., Anderson D.J.;
RT "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-
RT coupled receptor family.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
CC -!- FUNCTION: Orphan receptor. May regulate nociceptor function and/or
CC development, including the sensation or modulation of pain.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000305}.
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DR EMBL; AF518248; AAQ08320.1; -; Genomic_DNA.
DR RefSeq; NP_982296.1; NM_203470.1.
DR AlphaFoldDB; Q7TN39; -.
DR SMR; Q7TN39; -.
DR STRING; 10116.ENSRNOP00000028126; -.
DR GeneID; 309133; -.
DR KEGG; rno:309133; -.
DR UCSC; RGD:738044; rat.
DR CTD; 386746; -.
DR RGD; 738044; Mrgprg.
DR eggNOG; ENOG502TKZP; Eukaryota.
DR InParanoid; Q7TN39; -.
DR PhylomeDB; Q7TN39; -.
DR PRO; PR:Q7TN39; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd15111; 7tmA_MrgprG; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR InterPro; IPR027336; MRGPCRG.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF32; PTHR11334:SF32; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02108; MRGPCRFAMILY.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..289
FT /note="Mas-related G-protein coupled receptor member G"
FT /id="PRO_0000069769"
FT TOPO_DOM 1..13
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..80
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..164
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..200
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..289
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 289 AA; 32212 MW; 1D4C27EF394311E9 CRC64;
MLSIFNIWGT FNRVLFFLSL TVSLAGLAGN TLLLWHLGLR IKKGPFNTYL LHLAAADFLF
LSCQVGFSIA KIASGYEDTL YFPVTFLWFA VGLWLLAAFI VDCCLSYMFP SFCGPNCRPR
YTSFVLCLVI WALTMLAVLL PANACGLLYN RMSLLVCLKY HWVSVVWLGV LASTACGASM
FLLVFGNCCS SQPPSKFCKL AQCSGILLFF CRLPLVFYWC LRPVIKFLLP FFFPLATLLA
CIDSSAKPLL YYLKGRQLRK EPLQVALNRA LGEESQSSSG GISLPMSRV
