MRGRH_MOUSE
ID MRGRH_MOUSE Reviewed; 321 AA.
AC Q99MT8; Q149S2;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Mas-related G-protein coupled receptor member H;
DE AltName: Full=G-protein coupled receptor 90;
GN Name=Mrgprh; Synonyms=Gpr90, Mrgh;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11273702; DOI=10.1006/jmbi.2001.4520;
RA Wittenberger T., Schaller H.C., Hellebrand S.;
RT "An expressed sequence tag (EST) data mining strategy succeeding in the
RT discovery of new G-protein coupled receptors.";
RL J. Mol. Biol. 307:799-813(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor. May regulate nociceptor function and/or
CC development, including the sensation or modulation of pain (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF295365; AAK01865.1; -; mRNA.
DR EMBL; BC116696; AAI16697.1; -; mRNA.
DR EMBL; BC117525; AAI17526.1; -; mRNA.
DR CCDS; CCDS28395.1; -.
DR RefSeq; NP_109651.1; NM_030726.1.
DR AlphaFoldDB; Q99MT8; -.
DR SMR; Q99MT8; -.
DR STRING; 10090.ENSMUSP00000074768; -.
DR GlyGen; Q99MT8; 2 sites.
DR PaxDb; Q99MT8; -.
DR PRIDE; Q99MT8; -.
DR ProteomicsDB; 291406; -.
DR DNASU; 80978; -.
DR Ensembl; ENSMUST00000075296; ENSMUSP00000074768; ENSMUSG00000059408.
DR GeneID; 80978; -.
DR KEGG; mmu:80978; -.
DR UCSC; uc008alg.1; mouse.
DR CTD; 80978; -.
DR MGI; MGI:1934134; Mrgprh.
DR VEuPathDB; HostDB:ENSMUSG00000059408; -.
DR eggNOG; ENOG502RTWA; Eukaryota.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q99MT8; -.
DR OMA; GLENFFC; -.
DR OrthoDB; 1136752at2759; -.
DR PhylomeDB; Q99MT8; -.
DR TreeFam; TF336336; -.
DR BioGRID-ORCS; 80978; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q99MT8; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q99MT8; protein.
DR Bgee; ENSMUSG00000059408; Expressed in hindlimb stylopod muscle and 7 other tissues.
DR ExpressionAtlas; Q99MT8; baseline and differential.
DR Genevisible; Q99MT8; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001595; F:angiotensin receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR InterPro; IPR026221; MRGPCRH.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF60; PTHR11334:SF60; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PRINTS; PR02113; MRGPCRH.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..321
FT /note="Mas-related G-protein coupled receptor member H"
FT /id="PRO_0000069770"
FT TOPO_DOM 1..35
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..225
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..271
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..320
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 23
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 321 AA; 36911 MW; 03712FB7205F475E CRC64;
MEPLAMTLYP LESTQPTRNK TPNETTWSSE HTDDHTYFLV SLVICSLGLA GNGLLIWFLI
FCIKRKPFTI YILHLAIADF MVLLCSSIMK LVNTFHIYNM TLESYAILFM IFGYNTGLHL
LTAISVERCL SVLYPIWYQC QRPKHQSAVA CMLLWALSVL VSGLENFFCI LEVKPQFPEC
RYVYIFSCIL TFLVFVPLMI FSNLILFIQV CCNLKPRQPT KLYVIIMTTV ILFLVFAMPM
KVLLIIGYYS SSLDDSVWDS LPYLNMLSTI NCSINPIVYF VVGSLRRKRS RKSLKEALQK
VFEEKPVVAS RENVTQFSLP S
