ID   MRGRH_RAT               Reviewed;         321 AA.
AC   Q7TN38;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Mas-related G-protein coupled receptor member H;
GN   Name=Mrgprh; Synonyms=Mrgh;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=12909716; DOI=10.1073/pnas.1732949100;
RA   Zylka M.J., Dong X., Southwell A.L., Anderson D.J.;
RT   "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-
RT   coupled receptor family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
CC   -!- FUNCTION: Orphan receptor. May regulate nociceptor function and/or
CC       development, including the sensation or modulation of pain.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF518249; AAQ08321.1; -; Genomic_DNA.
DR   RefSeq; NP_001002281.1; NM_001002281.1.
DR   RefSeq; XP_006227944.1; XM_006227882.3.
DR   RefSeq; XP_017445004.1; XM_017589515.1.
DR   RefSeq; XP_017445005.1; XM_017589516.1.
DR   RefSeq; XP_017445006.1; XM_017589517.1.
DR   AlphaFoldDB; Q7TN38; -.
DR   SMR; Q7TN38; -.
DR   STRING; 10116.ENSRNOP00000020070; -.
DR   GlyGen; Q7TN38; 1 site.
DR   PaxDb; Q7TN38; -.
DR   GeneID; 404641; -.
DR   KEGG; rno:404641; -.
DR   CTD; 116511; -.
DR   RGD; 738049; Mrgprh.
DR   eggNOG; ENOG502RTWA; Eukaryota.
DR   HOGENOM; CLU_009579_4_1_1; -.
DR   InParanoid; Q7TN38; -.
DR   OMA; GLENFFC; -.
DR   OrthoDB; 1136752at2759; -.
DR   PhylomeDB; Q7TN38; -.
DR   TreeFam; TF336336; -.
DR   PRO; PR:Q7TN38; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000014965; Expressed in quadriceps femoris and 2 other tissues.
DR   ExpressionAtlas; Q7TN38; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001595; F:angiotensin receptor activity; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR026234; MRGPCRFAMILY.
DR   InterPro; IPR026221; MRGPCRH.
DR   PANTHER; PTHR11334; PTHR11334; 1.
DR   PANTHER; PTHR11334:SF60; PTHR11334:SF60; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR02108; MRGPCRFAMILY.
DR   PRINTS; PR02113; MRGPCRH.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..321
FT                   /note="Mas-related G-protein coupled receptor member H"
FT                   /id="PRO_0000069771"
FT   TOPO_DOM        1..35
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        57..71
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        93..102
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..126
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        127..147
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        169..188
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        210..225
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        247
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..271
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        272..320
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        23
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   321 AA;  36780 MW;  763649B4D06D5D0A CRC64;
     MEPLATTLCP QECTQTTRNE TPNETTWSSE HVTKYTYISI SLVICSLGLV GNGLLIWFLI
     FCIKRKPFTI YILHLAFADF MVLLCSSIIQ LVNTFHIYDS TLVSYAVLFM IFGYNTGLHL
     LTAISVERCL SVLYPIWYHC RRPKHQSTVA CTLLWALSVL VSGLENFFCI LEVKPQFPEC
     RYVYIFSCTL TFLVFVPLMV FSNLILFIQV CCNLKPRQPA KLYVIIMATV ILFLVFAMPM
     KVLLIIGYYS NSTDASVWKS LPYLNMLSTI NCSINPIVYF VVGSLRRKRS RKSLKEALQK
     VFEEKPVVAS RENEVQFSLP L