MRGX1_MOUSE
ID MRGX1_MOUSE Reviewed; 322 AA.
AC Q8CIP3;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Mas-related G-protein coupled receptor member X1;
DE AltName: Full=Mas-related G-protein coupled receptor member C11;
DE AltName: Full=Sensory neuron-specific G-protein coupled receptor 1;
GN Name=Mrgprx1 {ECO:0000312|MGI:MGI:3033139};
GN Synonyms=Mrgc11 {ECO:0000312|EMBL:AAN64385.1},
GN Mrgprc11 {ECO:0000312|MGI:MGI:3033139};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAN64385.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAN64385.1};
RX PubMed=12397184; DOI=10.1073/pnas.192565799;
RA Han S.-K., Dong X., Hwang J.-I., Zylka M.J., Anderson D.J., Simon M.I.;
RT "Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively
RT activated by RF-amide-related peptides through the Galpha q/11 pathway.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14740-14745(2002).
CC -!- FUNCTION: Orphan receptor activated by neuropeptides terminating in
CC Arg-Phe or Arg-Phe-amide. Mediates its action by association with G
CC proteins that activate a phosphatidylinositol-calcium second messenger
CC system. Its effect is mediated by G(q) and G(11) proteins. May regulate
CC the function of nociceptive neurons by modulation of pain perception.
CC {ECO:0000250|UniProtKB:Q96LB2, ECO:0000269|PubMed:12397184}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in a subset of IB4-positive small
CC diameter nociceptive dorsal root neurons.
CC {ECO:0000269|PubMed:12397184}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY152435; AAN64385.1; -; mRNA.
DR CCDS; CCDS21299.1; -.
DR RefSeq; NP_997423.1; NM_207540.3.
DR AlphaFoldDB; Q8CIP3; -.
DR SMR; Q8CIP3; -.
DR STRING; 10090.ENSMUSP00000091954; -.
DR BindingDB; Q8CIP3; -.
DR ChEMBL; CHEMBL3341576; -.
DR GlyGen; Q8CIP3; 1 site.
DR PaxDb; Q8CIP3; -.
DR PRIDE; Q8CIP3; -.
DR DNASU; 404242; -.
DR Ensembl; ENSMUST00000094390; ENSMUSP00000091954; ENSMUSG00000070552.
DR GeneID; 404242; -.
DR KEGG; mmu:404242; -.
DR UCSC; uc009hal.1; mouse.
DR CTD; 259249; -.
DR MGI; MGI:3033139; Mrgprx1.
DR VEuPathDB; HostDB:ENSMUSG00000070552; -.
DR eggNOG; ENOG502RTWA; Eukaryota.
DR GeneTree; ENSGT01030000234639; -.
DR HOGENOM; CLU_009579_4_1_1; -.
DR InParanoid; Q8CIP3; -.
DR OMA; NMSAIIC; -.
DR OrthoDB; 1123658at2759; -.
DR PhylomeDB; Q8CIP3; -.
DR TreeFam; TF336336; -.
DR BioGRID-ORCS; 404242; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8CIP3; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8CIP3; protein.
DR Bgee; ENSMUSG00000070552; Expressed in lip and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; ISO:MGI.
DR GO; GO:0007635; P:chemosensory behavior; IDA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IGI:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR026234; MRGPCRFAMILY.
DR InterPro; IPR027338; MRGPCRX1/MRGPCRX2.
DR PANTHER; PTHR11334; PTHR11334; 1.
DR PANTHER; PTHR11334:SF27; PTHR11334:SF27; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR02108; MRGPCRFAMILY.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..322
FT /note="Mas-related G-protein coupled receptor member X1"
FT /id="PRO_0000283731"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..179
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..223
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..257
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..322
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 322 AA; 36810 MW; 1E03ECD5A4AF88DC CRC64;
MDPTISSHDT ESTPLNETGH PNCTPILTLS FLVLITTLVG LAGNTIVLWL LGFRMRRKAI
SVYILNLALA DSFFLCCHFI DSLLRIIDFY GLYAHKLSKD ILGNAAIIPY ISGLSILSAI
STERCLCVLW PIWYHCHRPR NMSAIICALI WVLSFLMGIL DWFSGFLGET HHHLWKNVDF
IITAFLIFLF MLLSGSSLAL LLRILCGPRR KPLSRLYVTI ALTVMVYLIC GLPLGLYLFL
LYWFGVHLHY PFCHIYQVTA VLSCVNSSAN PIIYFLVGSF RQHRKHRSLK RVLKRALEDT
PEEDEYTDSH LHKTTEISES RY
